Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 376–400 of 27,380 studies, newest first · page 16 of 1096.
September 2026 25
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2026-09-23
Evaluating biomarkers and prediction models: predictive utility analysis with E2P Simulator
16/100 ⚠ Preprint — not yet peer-reviewed Risk factors PsyArXiv
Key finding: Starting from effect size or model performance estimates, the workflow simulates expected real-world performance in a target population and summarizes it across complementary metrics including positive and negative predictive value, Precision-Recall AUC, and Net Benefit. +4 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-23
Large-Scale Genome-wide association study identified Shared Genetic Risk SNPs Correlates in Epilepsy and Alzheimer's Disease
16/100 ⚠ Preprint — not yet peer-reviewed Genetics Research Square
Key finding: Inverse-variance weighted MR indicated that genetically predicted focal epilepsy with hippocampal sclerosis was associated with increased odds of AD (OR=3.99, 95% CI 1.17–13.61; P=0.027). +4 more findings
Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-23
Alcohol use disorder accelerates age-related cognitive decline
16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv (preprint)
Key finding: ObjectiveTo investigate whether a lifetime history of DSM-5 AUD and correlated indices of alcohol consumption are associated with accelerated age-related cognitive decline in middle-aged and older adults. +4 more findings
Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-23
Multimorbidity and Medication Order Patterns in Skilled Nursing Facilities: A Real-World Evidence Study
16/100 ⚠ Preprint — not yet peer-reviewed Disparities medRxiv (preprint)
Key finding: Rates varied across comorbidity combinations: ADRD was associated with lower medication order prevalence, while cardiometabolic multimorbidity profiles associated with higher prevalence. +1 more finding
Scored 20 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-23
Distinct lipid mediator profiles in brain and liver tissues in Alzheimer's disease
16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology medRxiv (preprint)
Key finding: Emerging evidence suggests that AD-related inflammation may reflect systemic metabolic changes, however, peripheral organs remain understudied. +2 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-23
Prevalence of dementia among community-dwelling older adults in rural Uganda: findings from DEPEND Uganda (Dementia Epidemiology, unmet need and co-developing solutions in Uganda)
16/100 ⚠ Preprint — not yet peer-reviewed Disparities medRxiv (preprint)
Key finding: Dementia was associated with increased age and lower educational attainment.
Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-23
Integrated genomic meta-analysis identifies cell-type-specific signatures and targets in early Alzheimer's disease
16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)
Key finding: We integrated multiomic findings using Meta-Analysis by Information Content (MAIC), a computational method which combines genomic data from diverse experimental sources. +4 more findings
Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-23
Clinician Perspectives on Automated Facial Analysis for Pain Assessment: A Cross-Sectional Survey of Physicians, Advanced Practice Providers, and Nurses
16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv (preprint)
Key finding: These findings suggest clinicians view automated facial-analysis systems as potentially valuable adjuncts for pain monitoring, particularly in communication-impaired populations, while emphasizing the importance of accuracy, fairness, explainability, and workflow integration during system development and implementation.
Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-23
Adaptation and Validation of Brief Tablet-Based Cognitive Assessment Tool in Uganda
16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv (preprint)
Key finding: For TabCAT tests, there were no notable floor or ceiling effects, and test scores were associated with age and education as expected. +2 more findings
Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-23
Single-cell atlas of transcriptomic vulnerability across brain disorders
52/100 ✓ Peer-reviewed Disease mechanisms Nature
Key finding: Exploring the neuropsychiatric symptoms (NPSs) that frequently accompany AD, we find an increased abundance of deep-layer excitatory neurons associated with a broad range of NPSs.
Full summary, score breakdown and related studies → Original source
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2026-09-22
Artificial Intelligence for Alzheimer’s Disease Detection Across Neuroimaging and Speech: A Reproducible Cross-Modal Secondary Analysis
16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools Research Square
Key finding: Only 5/26 primary studies (19.2%) explicitly evaluated external, cross-domain, or cross-language generalization, 5/26 (19.2%) used explicit multimodal input, and 4/26 (15.4%) emphasized explainability or uncertainty. +4 more findings
Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-22
Diagnostic Labels and Measurement Timing Drive Systematic Inconsistency in ADNI Neuroimaging Data
16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools bioRxiv
Key finding: In this paper, we showed that ADNI contains three interacting sources of bias with direct implications for machine learning: (a) diagnostic label inconsistency, (b) technical measurement drift, and (c) longitudinal survivor bias. +2 more findings
Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-22
Knowledge predicts attitudes toward dementia among hospital nurses in Saudi Arabia: a cross-sectional study
16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety Research Square
Key finding: Nurses showed moderate knowledge and positive attitudes, with knowledge closely linked to attitudes. +2 more findings
Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-22
Public Preferences for Autonomy-Enhancing Dementia Care in Ireland: A Protocol for a Discrete Choice Experiment
41/100 ✓ Peer-reviewed Caregiving HRB Open Res
Key finding: This study is one the first to account of attribute development for a DCE examining the public preferences for autonomy enhancing dementia care in Ireland. +4 more findings
Full summary, score breakdown and related studies → Original source
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2026-09-22
Separating ECog scale-score information from dyad availability: observation-process contributions to dyadic prediction of cognitive impairment in ADNI
16/100 ⚠ Preprint — not yet peer-reviewed Caregiving Research Square
Key finding: The conventional model (M2) concordance index (C-index) was 0.680, but fell to 0.649 when missingness indicators were removed. +3 more findings
Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-22
Panel-Gene Transcriptomic Associations and Published-Variant Architecture in Parkinson Disease
16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square
Key finding: Inverse-variance random-effects meta-analysis (DerSimonian–Laird) produced 419 analyzable genes, 91 at Benjamini–Hochberg FDR < 0.05, and 56 high-confidence genes (FDR < 0.05, measured in ≥ 3 cohorts, direction-concordant in ≥ 70% of cohorts, and nominally significant in ≥ 2 cohorts).
Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-22
Amyloid precursor protein: an Achilles’ heel to exploit in the treatment of prostate cancer
16/100 ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE bioRxiv
Key finding: Drugs that target APP have already been developed for AD and our data suggests they offer an exciting opportunity for repurposing in the treatment of prostate cancer.
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-22
Genetically predicted multisite chronic pain is associated with lower cognitive performance: a bidirectional Mendelian randomization study with NHANES contextual evidence
16/100 ⚠ Preprint — not yet peer-reviewed Genetics Research Square
Key finding: Genetically predicted MCP was associated with lower cognitive performance (IVW β=−0.361, 95% CI − 0.424 to − 0.299, p = 3.65×10⁻³⁰) with high heterogeneity (I²≈83.5%) and no directional pleiotropy. +3 more findings
Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-22
The value of a family history to distinguish monogenic from polygenic amyotrophic lateral sclerosis
16/100 ⚠ Preprint — not yet peer-reviewed Lewy body dementia medRxiv (preprint)
Key finding: Simulation results were benchmarked against real-world population estimates, over a wide range of demographic and genetic parameters.
Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-22
The United States CADASIL Consortium: Baseline Findings from a Natural History Study
16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv (preprint)
Key finding: Compared with controls, adjusted odds of classification into a more impaired CDR category were higher in all tiers (OR 2.55-5.08, 95% CI 1.22-11.34).
Scored 41 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-22
Genetic Associations with Alzheimer's, Lewy Body and Vascular Neuropathology Reveal Shared and Distinct Biological Pathways
16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)
Key finding: Genetic data was generated on the Illumina Neurobooster array and analysed using standard analyses pipelines in PLINK. +4 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-22
Multi-scale 3D CNN with imbalance-aware training for structural MRI-based six-class Alzheimer disease staging
48/100 ✓ Peer-reviewed Brain scans and imaging Computers in Biology and Medicine
Key finding: Paired ablation analysis showed that weighted sampling did not improve aggregate metrics but increased subjective memory complaint precision, recall, and F1, with all corresponding 95% confidence intervals excluding zero. +1 more finding
Full summary, score breakdown and related studies → Original source
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2026-09-22
Ceperognastat in Early Symptomatic Alzheimer Disease: A Randomized Clinical Trial
64/100 ✓ Peer-reviewed Clinical trials JAMA
Key finding: No benefits were demonstrated for secondary clinical end points. +2 more findings
Full summary, score breakdown and related studies → Original source
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2026-09-21
Machine learning on subcortical brain features: A study of sample size efficiency for neurodegenerative disease classification
16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools bioRxiv
Key finding: Learning curve analysis showed that classification performance was driven by the training sample size and the magnitude of anatomical group differences, and can be used to optimize future model selection tasks in dementia and other brain disorders.
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-21
Comparative Performance of Conventional, Informant-Based, and Digital Cognitive Screening Tools in Community-Dwelling Older Adults: A Cross-Sectional Study
16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment Research Square
Key finding: This study provides quantitative evidence supporting the complementary use of multiple cognitive assessment tools. +3 more findings
Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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