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49/100

✓ Peer-reviewed alzhub usefulness score 49 out of 100. Brain tissue and pathology

Topic: Amyloid, tau and blood-test diagnosis

Plain-language summary

= 0.015). In this autopsy-confirmed cohort, seizure susceptibility was associated with advanced tau pathology and CAA in AD. In DLB, exploratory analyses suggested a possible association between vascular pathology and seizures; however, these findings should be interpreted cautiously. Overall, the results support potentially distinct pathologic contributions to seizure susceptibility across dementia subtypes. Limitations include the use of advanced-stage pathologic samples, which may limit generalizability to earlier disease stages.

What this study adds

Evidence grade: Moderate

This is a follow-up (cohort) study. In this autopsy-confirmed cohort, seizure susceptibility was associated with advanced tau pathology and CAA in Alzheimer's disease, while exploratory analyses in DLB suggested a possible association with vascular pathology. These findings support distinct pathologic contributions to seizures across dementia subtypes, but the use of advanced-stage samples may limit generalizability to earlier disease stages.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Ting, S. K. S., Saffari, S. E., Zhan, S. J., Gosavi, T. D., Shahul Hameed, V., Li, W., et al. (2026). Neuropathologic Correlates of Seizures in Patients With Alzheimer Disease and Dementia With Lewy Bodies. Neurology. https://doi.org/10.1212/wnl.0000000000218277

Vancouver

Ting SKS, Saffari SE, Zhan SJ, Gosavi TD, Shahul Hameed V, Li W, et al. Neuropathologic Correlates of Seizures in Patients With Alzheimer Disease and Dementia With Lewy Bodies. Neurology. 2026. doi:10.1212/wnl.0000000000218277. PMID: 42385113.

BibTeX

@article{ting2026-42385113,
  author  = {Ting, Simon Kang Seng and Saffari, Seyed Ehsan and Zhan, Stella Jinran and Gosavi, Tushar Divakar and Shahul Hameed, V. and Li, Weishan and Shah, Jinesh Mukesh and Lin, Shawn Zhi Zheng and others},
  title   = {{Neuropathologic Correlates of Seizures in Patients With Alzheimer Disease and Dementia With Lewy Bodies}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/wnl.0000000000218277},
  pmid    = {42385113},
  url     = {https://doi.org/10.1212/wnl.0000000000218277}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

How to read this study

Design: this is a follow-up (cohort) study. People are observed over time and not assigned to anything, so an association can reflect other differences between groups. Look at how long follow-up lasted, how many dropped out, and whether the authors adjusted for age, education and other health conditions.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded moderate. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Moderate means the abstract mentions a cohort, case-control or longitudinal design. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

New to reading papers? Six questions to ask of any Alzheimer’s study · how we score.

Key findings

In this autopsy-confirmed cohort, seizure susceptibility was associated with advanced tau pathology and CAA in AD.
In DLB, exploratory analyses suggested a possible association between vascular pathology and seizures; however, these findings should be interpreted cautiously.
Overall, the results support potentially distinct pathologic contributions to seizure susceptibility across dementia subtypes.
Limitations include the use of advanced-stage pathologic samples, which may limit generalizability to earlier disease stages.

Why it matters

In this autopsy-confirmed cohort, seizure susceptibility was associated with advanced tau pathology and CAA in Alzheimer's disease, while exploratory analyses in DLB suggested a possible association with vascular pathology. These findings support distinct pathologic contributions to seizures across dementia subtypes, but the use of advanced-stage samples may limit generalizability to earlier disease stages.

Study details

Study designcohort study
Evidence strengthModerate

How this study scored 49/100

Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Neurology)
Journal's citation record	4 / 4	Neurology: journal h-index 525 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.5 citations a year over 2 year(s) since 2026
Impact for its field and year	3 / 6	Cited 4.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Adeline Su Lyn Ng: h-index 24 (OpenAlex, whole career)
Institution's track record	1 / 3	National University of Singapore: institution h-index 1,166 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 42385113)
Free to read	0 / 2	Behind a paywall — scores zero
Total	49 / 100	—

What each of these 20 components measures, and what this score is not →

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