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Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration
Katherine R Birditt, Kalliopi Mavromati, Peter Swann, Terence Quinn, Atticus H Hainsworth, Lynne Hughes, John T O'Brien, William McEwan et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026-07
Topic: Plasma and spinal-fluid biomarkers
Two components were identified. Proinflammatory Component 2 was elevated in AD/MCI and in Black/African American participants, and strongly associated with poorer cognition (independently of neurofilament light [NfL], phosphorylated tau 217 [p-tau217], and glial fibrillary acidic protein [GFAP]). Inflammatory Component 1 showed an indirect association with cognition, mediated by neurodegeneration (plasma NfL). Plasma inflammation profiles were associated with poorer cognition via direct and neurodegeneration-mediated pathways, supporting their potential use as stratification markers in AD therapeutics.
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APA 7th
Birditt, K. R., Mavromati, K., Swann, P., Quinn, T., Hainsworth, A. H., Hughes, L., et al. (2026). Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.71642
Vancouver
Birditt KR, Mavromati K, Swann P, Quinn T, Hainsworth AH, Hughes L, et al. Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026. doi:10.1002/alz.71642. PMID: 42363728.
BibTeX
@article{birditt2026-42363728,
author = {Birditt, Katherine R and Mavromati, Kalliopi and Swann, Peter and Quinn, Terence and Hainsworth, Atticus H and Hughes, Lynne and O'Brien, John T and McEwan, William and others},
title = {{Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
doi = {10.1002/alz.71642},
pmid = {42363728},
url = {https://doi.org/10.1002/alz.71642}
}
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Key findings
- Proinflammatory Component 2 was elevated in AD/MCI and in Black/African American participants, and strongly associated with poorer cognition (independently of neurofilament light [NfL], phosphorylated tau 217 [p-tau217], and glial fibrillary acidic protein [GFAP]).
- Inflammatory Component 1 showed an indirect association with cognition, mediated by neurodegeneration (plasma NfL).
- Plasma inflammation profiles were associated with poorer cognition via direct and neurodegeneration-mediated pathways, supporting their potential use as stratification markers in AD therapeutics.
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Study details
- Evidence strengthModerate
How this study scored 53/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and free to read, so those were left out: it earned 31 of the 59 points we could judge it on, which is 53 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | 2 / 3 | PubMed indexes it as a multicentre study |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42363728) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 31 / 59 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 31 of the 59 points we could judge it on is 53 out of 100. |
| Total | 53 / 100 | — |
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