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Plasma Amyloid-β 1-40 and Postoperative Delirium After Cardiac Surgery
Christine A F von Arnim, Monika Sadlonova, Carlotta Derad, Maike Hohberg, Christopher M Celano, Irina Günther, Tobias Titsch, Iryna Krasiuk et al.. JAMA network open, 2026-07-01
Topic: Plasma and spinal-fluid biomarkers
Plain-language summary
Of 504 enrolled patients, 491 completed POD assessment (mean [SD] age, 68.4 [8.3] years; 385 [78.4%] male), of whom 106 (21.6%) developed POD. In multiple linear regression, pTau217 (β = -0.51; 95% CI, -0.89 to -0.12; P = .01) and age (β = -0.12; 95% CI, -0.16 to -0.08; P < .001) remained significant factors associated with lower MoCA scores. Patients who developed POD had higher preoperative Aβ1-40, Aβ1-42, pTau217, and Aβ1-40/Aβ1-42 × pTau217, and lower Aβ1-42/Aβ1-40. Aβ1-40 was the independent biomarker most strongly associated with POD (area under the receiver operating curve [AUC], 0.65; 95% CI, 0.59-0.71; P < .001). Combining biomarkers with clinical factors improved risk estimation (AUC, 0.74; 95% CI, 0.69-0.79; P < .001) compared with clinical factors alone (AUC, 0.73; 95% CI, 0.67-0.78; P < .001). A combined model including MoCA achieved an AUC of 0.77 (95% CI, 0.72-0.82; P < .001), driven primarily by Aβ1-40. CONCLUSIONS AND RELEVANCE: In this prospective cohort study, preoperative Aβ1-40 showed the strongest association with POD risk among the measured biomarkers. These findings suggest that preoperative plasma Aβ1-40 may contribute to POD risk stratification, but further research is needed to validate these findings and determine clinical utility.
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APA 7th
von Arnim, C. A. F., Sadlonova, M., Derad, C., Hohberg, M., Celano, C. M., Günther, I., et al. (2026). Plasma Amyloid-β 1-40 and Postoperative Delirium After Cardiac Surgery. JAMA network open. https://doi.org/10.1001/jamanetworkopen.2026.25730
Vancouver
von Arnim CAF, Sadlonova M, Derad C, Hohberg M, Celano CM, Günther I, et al. Plasma Amyloid-β 1-40 and Postoperative Delirium After Cardiac Surgery. JAMA network open. 2026. doi:10.1001/jamanetworkopen.2026.25730. PMID: 42518233.
BibTeX
@article{vonarnim2026-42518233,
author = {von Arnim, Christine A F and Sadlonova, Monika and Derad, Carlotta and Hohberg, Maike and Celano, Christopher M and Günther, Irina and Titsch, Tobias and Krasiuk, Iryna and others},
title = {{Plasma Amyloid-β 1-40 and Postoperative Delirium After Cardiac Surgery}},
journal = {JAMA network open},
year = {2026},
doi = {10.1001/jamanetworkopen.2026.25730},
pmid = {42518233},
url = {https://doi.org/10.1001/jamanetworkopen.2026.25730}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Of 504 enrolled patients, 491 completed POD assessment (mean [SD] age, 68.4 [8.3] years; 385 [78.4%] male), of whom 106 (21.6%) developed POD.
- In multiple linear regression, pTau217 (β = -0.51; 95% CI, -0.89 to -0.12; P = .01) and age (β = -0.12; 95% CI, -0.16 to -0.08; P < .001) remained significant factors associated with lower MoCA scores.
- Patients who developed POD had higher preoperative Aβ1-40, Aβ1-42, pTau217, and Aβ1-40/Aβ1-42 × pTau217, and lower Aβ1-42/Aβ1-40.
- Aβ1-40 was the independent biomarker most strongly associated with POD (area under the receiver operating curve [AUC], 0.65; 95% CI, 0.59-0.71; P < .001).
- Combining biomarkers with clinical factors improved risk estimation (AUC, 0.74; 95% CI, 0.69-0.79; P < .001) compared with clinical factors alone (AUC, 0.73; 95% CI, 0.67-0.78; P < .001).
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Study details
- Study designcohort study
- Effect size78.4%; 21.6%
- Evidence strengthModerate
How this study scored 73/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for sample size and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 41 of the 56 points we could judge it on, which is 73 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA network open) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42518233) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 41 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 41 of the 56 points we could judge it on is 73 out of 100. |
| Total | 73 / 100 | — |
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