Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 22,701–22,725 of 27,380 studies, newest first · page 909 of 1096.
March 2007 15
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2007-03-01
Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report
51/100 ✓ Peer-reviewed Brain tissue and pathology Archives of neurology
Key finding: Patient A 76-year-old man with a clinical diagnosis of dementia with Lewy bodies underwent fluorodeoxyglucose (18)F and PiB positron emission tomographic brain scans. +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-03-01
Longitudinal change in cognitive performance among individuals with mild cognitive impairment
58/100 ✓ Peer-reviewed Cognitive tests and assessment Neuropsychology
Key finding: At follow-up, the participants were divided into 4 groups: (a) controls: participants who were normal at both baseline and follow-up (n = 33), (b) stables: participants with MCI whose Clinical Dementia Rating-Sum of Boxes (CDR-SB) score did not differ between the first and last evaluations (n = 22), (c) decliners: participants with MCI whose CDR-SB score declined between the first and last evaluations (n = 95), and (d) converters: participants who received a clinical diagnosis of Alzheimer's disease during the follow-up period (n = 47). +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-03-01
FMRP mediates mGluR5-dependent translation of amyloid precursor protein
45/100 ✓ Peer-reviewed Risk genes beyond APOE PLoS biology
Key finding: Fragile X mental retardation protein (FMRP) is a cytoplasmic mRNA binding protein whose expression is lost in fragile X syndrome. +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-03-01
Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention
41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of Alzheimer's disease : JAD
Key finding: Neurobiological studies of similarly aged DS autopsy cases provide further evidence of activation of plasticity mechanisms. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-03-01
A longitudinal study of language decline in Alzheimer's disease and frontotemporal dementia
51/100 ✓ Peer-reviewed Digital health tools Journal of the International Neuropsychological Society : JINS
Key finding: In Alzheimer's disease (AD), it is usually associated with global cognitive deficits. +2 more findings
Full summary, score breakdown and related studies → Original source
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2007-03-01
Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease
57/100 ✓ Peer-reviewed How common it is Archives of neurology
Key finding: The plasma Abeta42/Abeta40 ratio may be a useful premorbid biomarker for identifying cognitively normal elderly white subjects who are at increased risk for developing MCI or AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-03-01
Decisions to forgo hospitalization in advanced dementia: a nationwide study
53/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: Directives to forgo hospitalization for U.S. NH residents with advanced dementia are uncommon and are associated with the organizational features of the facilities caring for them and the intensity of end-of-life care practiced in the region, as well as individual resident characteristics. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-03-01
Correlates of physical health of informal caregivers: a meta-analysis
64/100 ✓ Peer-reviewed Caregiving The journals of gerontology. Series B, Psychological sciences and social sciences
Key finding: This meta-analysis integrates results from 176 studies on correlates of caregiver physical health.
Full summary, score breakdown and related studies → Original source
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2007-03-01
Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study
56/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Systemic inflammation is associated with ischemia and Alzheimer disease (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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2007-03-01
Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease
64/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Hippocampal and entorhinal cortex volumes were each largest in controls, intermediate in MCI nonconverters, and smallest in MCI converters to AD (37 of 139 patients converted to AD).
Full summary, score breakdown and related studies → Original source
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2007-03-01
DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers
58/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: We concluded that the differing temporal sequence of symptoms and clinical features of PDD and DLB justify distinguishing these disorders.
Full summary, score breakdown and related studies → Original source
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2007-03-01
IANA task force on nutrition and cognitive decline with aging
49/100 ✓ Peer-reviewed Prevention and risk The journal of nutrition, health & aging
Key finding: Cognitive impairment can be influenced by a number of factors. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-03-01
[Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer disease]
55/100 ✓ Peer-reviewed Treatments L'Encephale
Key finding: Compared to entry results, episodic memory decreased in group D + P but improved in group S + D. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-03-01
AMPA potentiator treatment of cognitive deficits in Alzheimer disease
66/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Patients treated with LY451395 did not show a statistically significant separation from patients taking placebo on the Alzheimer's Disease Assessment Scale-Cognitive Subscale, the primary outcome measure. +2 more findings
Full summary, score breakdown and related studies → Original source
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2007-03-01
Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study
66/100 ✓ Peer-reviewed Genetics Neurology
Key finding: The relationship between serum total cholesterol (TC) and dementia seems to be bidirectional. +4 more findings
Full summary, score breakdown and related studies → Original source
February 2007 10
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2007-02-28
Susac's syndrome: 1975-2005 microangiopathy/autoimmune endotheliopathy
36/100 ✓ Peer-reviewed Risk factors Journal of the neurological sciences
Key finding: Despite extensive evaluations, a procoagulant state has never been demonstrated.
Full summary, score breakdown and related studies → Original source
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2007-02-28
Calcium and neurodegeneration
36/100 ✓ Peer-reviewed Genetics Aging cell
Key finding: During aging, and particularly in neurodegenerative disorders, cellular Ca2+-regulating systems are compromised resulting in synaptic dysfunction, impaired plasticity and neuronal degeneration. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-02-28
Spatial navigation deficit in amnestic mild cognitive impairment
49/100 ✓ Peer-reviewed Mild cognitive impairment Proceedings of the National Academy of Sciences of the United States of America
Key finding: The amnestic MCI single-domain group was impaired significantly in subtests focused on allocentric orientation and at the beginning of the real space egocentric subtest, suggesting impaired memory for allocentric and real space configurations. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-02-27
AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides
40/100 ✓ Peer-reviewed How common it is BMC bioinformatics
Key finding: By identifying aggregation-prone segments in proteins, AGGRESCAN http://bioinf.uab.es/aggrescan/ shall facilitate (i) the identification of possible therapeutic targets for anti-depositional strategies in conformational diseases and (ii) the anticipation of aggregation phenomena during storage or recombinant production of bioactive polypeptides or polypeptide sets.
Full summary, score breakdown and related studies → Original source
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2007-02-27
GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models
42/100 ✓ Peer-reviewed Brain tissue and pathology The Journal of pharmacology and experimental therapeutics
Key finding: GSK189254 is >10,000-fold selective for human H(3) receptors versus other targets tested, and it exhibited potent functional antagonism (pA(2) = 9.06 versus agonist-induced changes in cAMP) and inverse agonism [pIC(50) = 8.20 versus basal guanosine 5'-O-(3-[(35)S]thio)triphosphate binding] at the human recombinant H(3) receptor. +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-02-22
Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants
69/100 ✓ Peer-reviewed Genetics Human molecular genetics
Key finding: A tiered strategy was used to follow-up significant variants from the discovery sample in four independent sample sets. +2 more findings
Full summary, score breakdown and related studies → Original source
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2007-02-21
Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications
36/100 ✓ Peer-reviewed Disease mechanisms Steroids
Key finding: Signaling mechanisms underlying estrogen-induced neuroprotection and synaptic plasticity are reviewed, including the important concepts of genomic versus nongenomic mechanisms, types of estrogen receptor involved and their subcellular targeting, and implicated downstream signaling pathways and mediators.
Full summary, score breakdown and related studies → Original source
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2007-02-21
CSF neurofilament proteins in the differential diagnosis of dementia
36/100 ✓ Peer-reviewed Biomarkers Journal of neurology, neurosurgery, and psychiatry
Key finding: In the diagnostic workup of relatively young dementia patients, CSF NFL levels may play a role in the discrimination between FTLD and EAD, especially in combination with Abeta42 and p-tau181 analysis. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-02-21
Aging effects on cerebral blood and cerebrospinal fluid flows
36/100 ✓ Peer-reviewed Vascular contributions Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Key finding: Total cerebral blood flow was (P<0.01) decreased significantly in the elderly group when compared with the young subjects with a linear correlation with age observed only in the elderly group (R(2)=0.7; P=0.05). +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-02-21
Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils
46/100 ✓ Peer-reviewed Inflammation and the immune system Molecular biology of the cell
Key finding: Primary mouse microglia can internalize fAbeta, but they do not degrade it efficiently. +3 more findings
Full summary, score breakdown and related studies → Original source
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