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Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults
Nicholas M Vogt, Jack F V Hunt, Nagesh Adluru, Yue Ma, Carol A Van Hulle, Douglas C Dean, Steven R Kecskemeti, Nathaniel A Chin et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021-05-13
Topic: Plasma and spinal-fluid biomarkers
We observed a significant CSF Aβ42 /Aβ40 × p-tau interaction on cortical neurite density index (NDI), but not orientation dispersion index or cortical thickness. The directionality of these interactive effects indicated: (1) among individuals with lower CSF p-tau, greater amyloid burden was associated with higher cortical NDI; and (2) individuals with greater amyloid and p-tau burden had lower cortical NDI, consistent with cortical neurodegenerative changes. NDI is a particularly sensitive marker for early cortical changes that occur prior to gross atrophy or development of cognitive impairment.
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APA 7th
Vogt, N. M., Hunt, J. F. V., Adluru, N., Ma, Y., Van Hulle, C. A., Dean, D. C., et al. (2022). Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.12364
Vancouver
Vogt NM, Hunt JFV, Adluru N, Ma Y, Van Hulle CA, Dean DC, et al. Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022. doi:10.1002/alz.12364. PMID: 33984184.
BibTeX
@article{vogt2022-33984184,
author = {Vogt, Nicholas M and Hunt, Jack F V and Adluru, Nagesh and Ma, Yue and Van Hulle, Carol A and Dean, Douglas C and Kecskemeti, Steven R and Chin, Nathaniel A and others},
title = {{Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2022},
doi = {10.1002/alz.12364},
pmid = {33984184},
url = {https://doi.org/10.1002/alz.12364}
}
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Key findings
- We observed a significant CSF Aβ42 /Aβ40 × p-tau interaction on cortical neurite density index (NDI), but not orientation dispersion index or cortical thickness.
- The directionality of these interactive effects indicated: (1) among individuals with lower CSF p-tau, greater amyloid burden was associated with higher cortical NDI; and (2) individuals with greater amyloid and p-tau burden had lower cortical NDI, consistent with cortical neurodegenerative changes.
- NDI is a particularly sensitive marker for early cortical changes that occur prior to gross atrophy or development of cognitive impairment.
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Study details
- Evidence strengthLow
How this study scored 45/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 25 of the 56 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33984184) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 25 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 25 of the 56 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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