Newest studies

Diagnostic value and difference of quantitative susceptibility mapping and voxel-based morphological analysis in patients with Alzheimer’s disease and mild cognitive impairment

44/100 ✓ Peer-reviewed Mild cognitive impairment Chinese Medical Journal

Key finding: To the Editor: With the aging of the population, the prevalence of Alzheimer’s disease (AD) has increased significantly. +4 more findings

• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Association of vitamin B12 deficiency in a dementia cohort with hippocampal atrophy on MRI

41/100 ✓ Peer-reviewed How common it is The Journal of Prevention of Alzheimer s Disease

Key finding: • This analysis consists of 567 participants revealed that vitamin B12 deficiency, not folate or vitamin B1 deficiency was associated with hippocampal atrophy detected by MRI-VSRAD analysis. • Vitamin B12 deficiency was associated with hyperhomocysteinemia. • Clear correlations were observed between hippocampal atrophy and vitamin B12 value. +3 more findings

• Brain Scans
• Lifestyle

Full summary, score breakdown and related studies → Original source

Decomposing Racial and Ethnic Disparities in Risk and Protective Factors of Dementia in the U.S

42/100 ✓ Peer-reviewed Getting a diagnosis Clinical Gerontologist

Key finding: Black participants had 2.883 times higher odds of developing dementia compared to Whites, while Hispanic participants had 1.230 times higher odds (not statistically significant). +4 more findings

• Health Equity
• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

A comprehensive review/expert statement on environmental risk factors of cardiovascular disease

52/100 ✓ Peer-reviewed Prevention and risk Cardiovascular Research

Key finding: Similarly, noise pollution, heat extremes, toxic chemicals, and light pollution significantly increase the risk of CVD through mechanisms involving oxidative stress, inflammation, and circadian disruption.

• Risk Factors
• Policy

Full summary, score breakdown and related studies → Original source

Bridging Silos: Aligning State Health Improvement, Aging, and Dementia Plans

29/100 ✓ Peer-reviewed Health systems and care delivery Journal of Public Health Management and Practice

Key finding: As states work to maximize limited resources while improving population outcomes, the strategic alignment of planning processes represents a significant opportunity. +3 more findings

Full summary, score breakdown and related studies → Original source

An Anti-tau Therapeutic Antibody Etalanetug (E2814): A Phase 1, First-in-human (FIH) Study of Single and Multiple Ascending Doses in Healthy Subjects

66/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders

Key finding: Etalanetug presented an adequate safety and immunogenicity profile in healthy adults. +2 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex

63/100 ✓ Peer-reviewed Brain scans and imaging Nature neuroscience

Key finding: Tau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer's disease, which is associated with neurodegeneration and cognitive decline. +2 more findings

• Brain Scans
• Genetics
• Early Stage

Full summary, score breakdown and related studies → Original source

Tailoring thresholds for interpreting plasma p-tau217 levels

58/100 ✓ Peer-reviewed Biomarkers Journal of neurology, neurosurgery, and psychiatry

Key finding: The optimal cut-offs differed between CU and CI groups. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

MRI contrast accumulation in features of cerebral small vessel disease: blood-brain barrier dysfunction or elevated vascular density?

43/100 ✓ Peer-reviewed Vascular contributions Fluids and Barriers of the CNS

Key finding: ), whereas the effect of region was only borderline-significant when comparing NAWM, WML peripheries and WML (p = 0.03) and non-significant for the other comparisons (p > 0.29). +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Assessing Palliative Care Needs in Two Rural Communities in Thailand Through a Household Survey

35/100 ✓ Peer-reviewed End-of-life care Journal of the Medical Association of Thailand

Key finding: In Mae Pa, the palliative care need prevalence was 2.03 per 1,000, among them, 84.62% had non-cancer conditions and 38.46% had neurodegenerative diseases with frailty and dementia. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Hospital readmissions of frail older individuals: the challenge of anticipating end-of-life care

34/100 ✓ Peer-reviewed End-of-life care Frontiers in Medicine

Key finding: The latter often experience a loss of functional independence and geriatric syndromes including falls, undernutrition and neurocognitive disorders (1) requiring significant care that generates health expenditure. +3 more findings

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia

36/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Aging Neuroscience

Key finding: Furthermore, pericytes residing abluminal on capillary endothelia demonstrate critical involvement in hemodynamic modulation through contractile regulation of microvascular tone, while concurrently maintaining BBB integrity through dynamic paracrine signaling. +4 more findings

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Transactive response DNA-binding protein 43 (TDP-43) proteinopathy: the complex biological and clinical findings in limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes, limbic-predominant amnestic neurodegenerative syndrome, and other mixed age-related major neurocognitive disorders

32/100 ✓ Peer-reviewed Brain tissue and pathology Current Opinion in Psychiatry

Key finding: As the term limbic-predominant age-related transactive response DNA-binding protein 43 (TDP-43) encephalopathy (LATE) was coined in 2019, more than 200 articles addressing the subject were published.

• Brain Biology
• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Association of heel bone mineral density with incident dementia among ageing adults: a population-based study from the UK Biobank

53/100 ✓ Peer-reviewed Long-term cohort studies Aging Clinical and Experimental Research

Key finding: ) had a 14% increase in the rate of dementia incidence (HR 1.14, 95% CI 1.06-1.23; P <.001), and each standard deviation (SD) decrease in eBMD was associated with a 49% increase in dementia risk (HR 1.49, 95% CI 1.19-1.86; P <.001). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Adherence to four dietary indices and the risk of all‐cause and cause‐specific dementia: Findings from the UK Biobank study

50/100 ✓ Peer-reviewed Long-term cohort studies Diabetes Obesity and Metabolism

Key finding: The analysis included 121 521 participants (mean age: 55.7 years; 53.5% women), followed for a median of 10.9 years. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Developing an explainable machine learning and fog computing-based visual rating scale for the prediction of dementia progression

42/100 ✓ Peer-reviewed Digital health tools Scientific Reports

Key finding: The results indicate that our proposed ML model achieves an impressive accuracy of 0.93, outperforming the MoCA score (0.90) and MMSE score (0.83). +1 more finding

• Digital Tools
• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

Artificial intelligence in neurodegenerative diseases research: a bibliometric analysis since 2000

43/100 ✓ Peer-reviewed Digital health tools Frontiers in Neurology

Key finding: This bibliometric review examines the evolving landscape of artificial intelligence (AI) in neurodegenerative diseases research from 2000 to March 16, 2025, utilizing data from 1,402 publications (1,159 articles, 243 reviews) indexed in the Web of Science Core Collection.

• Digital Tools
• Brain Scans

Full summary, score breakdown and related studies → Original source

Exploring the Immediate and Long-Term Effects of Immersive Virtual Reality on Behavioral and Psychological Symptoms of Dementia and Caregiver Burden: Longitudinal Observational Study

45/100 ✓ Peer-reviewed Caregiving JMIR Serious Games

Key finding: Significant improvements were observed after 1 month of VR intervention in both caregiver burden (Z=-3.095, P=.002, r=0.34) and neuropsychiatric symptoms (Z=-2.929, P=.003, r=0.32). +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Cerebrospinal Fluid p-Tau181/Amyloid Beta 42 Ratio Identifies Lymphatic-Venous Anastomosis Patients Who Respond to and Benefit from the Surgery for Relief of Cognitive Impairment with a Diagnostic Accuracy of 0.744

43/100 ✓ Peer-reviewed Getting a diagnosis ACS Omega

Key finding: High Resolution Image Download MS PowerPoint Slide Responders (R) and Non-Responders (NR) to lymphatic-venous anastomosis (LVA) surgery for relief of cognitive impairment show significant difference in their p-tau181/Aβ42 ratios via enzyme-linked immunosorbent assay (ELISA) of their cerebrospinal fluid (CSF). +2 more findings

• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

Future of Alzheimer's detection: Advancing diagnostic accuracy through the integration of qEEG and artificial intelligence

49/100 ✓ Peer-reviewed Getting a diagnosis NeuroImage

Key finding: This comprehensive review examines the integration of Quantitative Electroencephalography (qEEG) and Artificial Intelligence (AI) in the detection and diagnosis of Alzheimer's Disease (AD). +4 more findings

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores

37/100 ✓ Peer-reviewed Genetics Neurobiology of Aging

Key finding: SnATAC-derived ct-ADPRSs demonstrated considerably lower correlations among cell types (average r=0.071) than snRNA-derived ct-ADPRSs (average r=0.19), indicating their heightened cell-type specificity. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Enhancing protein O-GlcNAcylation in down syndrome mice mitigates memory dysfunctions through the rescue of mitochondrial bioenergetics, stress responses and pathological markers

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Redox biology

Key finding: In Alzheimer disease (AD), the reduced uptake of glucose in the brain results in aberrant O-GlcNAc cycling contributing to redox imbalance and neurodegeneration. +2 more findings

• Brain Biology
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Joint association of cognitive reserve and frailty with incident Alzheimer's disease and related dementias

52/100 ✓ Peer-reviewed Risk factors Behavioural brain research

Key finding: Cognitive reserve and frailty are factors associated with Alzheimer's disease and related dementias (ADRD). +4 more findings

Full summary, score breakdown and related studies → Original source

Differential associations of APOE and TREM2 variants with glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants support distinct disease mechanisms

63/100 ✓ Peer-reviewed Biomarkers Molecular psychiatry

Key finding: The results show that APOE4 is associated with elevated levels of plasma GFAP, and to a lesser extent, NEFL. +2 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Performance of Plasma Phosphorylated tau-217 in Patients on the Continuum of Alzheimer's Disease

57/100 ✓ Peer-reviewed Biomarkers International journal of molecular sciences

Key finding: Recent studies have demonstrated the high analytical and diagnostic performance of plasma p-tau217 using well-defined cohorts. +1 more finding

• Biomarkers
• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source