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Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype
Baril AA, Beiser AS, Sanchez E, Mysliwiec V, Redline S, Gottlieb DJ, O'Connor GT, Gonzales MM et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021-07-26
Topic: Brain proteins, microglia and lab models
Introduction We evaluated whether insomnia symptom severity was associated with cognitive function, and whether this relationship was modified by biomarkers associated with Alzheimer's disease risk. Methods We examined insomnia symptoms and neuropsychological performance 3.4 years later in 511 dementia-free Framingham Heart Study participants (62.65 ± 8.7 years, 50.9% male). Additionally, we explored insomnia symptoms combined with self-reported short habitual sleep duration and effect modification by apolipoprotein E (APOE) ε4 allele status.
Key findings
- Methods We examined insomnia symptoms and neuropsychological performance 3.4 years later in 511 dementia-free Framingham Heart Study participants (62.65 ± 8.7 years, 50.9% male).
- Additionally, we explored insomnia symptoms combined with self-reported short habitual sleep duration and effect modification by apolipoprotein E (APOE) ε4 allele status.
- Results More severe insomnia symptoms were associated with lower performance on global cognition, and immediate and delayed Logical Memory recall, especially when insomnia symptoms were combined with short sleep duration.
- The association between insomnia symptoms and poorer memory recall was more pronounced in APOE ε4 allele carriers.
Why it matters
This study evaluated whether insomnia symptom severity is linked to cognitive function and whether this relationship is modified by APOE genotype. It found that more severe insomnia symptoms were associated with lower performance on global cognition and memory recall.
Study details
- Effect size50.9%
- Evidence strengthLow
How this study scored 45/100
Published in a leading specialty journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record and senior author's track record, so those were left out: it earned 41 of the 92 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 14 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.3 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 3.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 10 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34310026) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 41 / 92 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 41 of the 92 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Baril, A. A., Beiser, A. S., Sanchez, E., Mysliwiec, V., Redline, S., Gottlieb, D. J., et al. (2022). Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.12405
Vancouver
Baril AA, Beiser AS, Sanchez E, Mysliwiec V, Redline S, Gottlieb DJ, et al. Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022. doi:10.1002/alz.12405. PMID: 34310026.
BibTeX
@article{baril2022-34310026,
author = {Baril, A. A. and Beiser, A. S. and Sanchez, E. and Mysliwiec, V. and Redline, S. and Gottlieb, D. J. and O'Connor, G. T. and Gonzales, M. M. and others},
title = {{Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2022},
doi = {10.1002/alz.12405},
pmid = {34310026},
url = {https://doi.org/10.1002/alz.12405}
}
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