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Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder
Miglis MG, Adler CH, Antelmi E, Arnaldi D, Baldelli L, Boeve BF, Cesari M, Dall'Antonia I et al.. The Lancet. Neurology, 2021-08-01
Topic: Brain proteins, microglia and lab models
Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving α-synuclein pathology, such as Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. Abnormal α-synuclein deposition occurs early in the neurodegenerative process across the central and peripheral nervous systems and might precede the appearance of motor symptoms and cognitive decline by several decades. These findings provide the rationale to develop reliable biomarkers that can better predict conversion to clinically manifest α-synucleinopathies. In addition, biomarkers of disease progression will be essential to monitor treatment response once disease-modifying therapies become available, and biomarkers of disease subtype will be essential to enable prediction of which subtype of α-synucleinopathy patients with isolated RBD might develop.
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APA 7th
Miglis, M. G., Adler, C. H., Antelmi, E., Arnaldi, D., Baldelli, L., Boeve, B. F., et al. (2021). Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder. The Lancet. Neurology. https://doi.org/10.1016/s1474-4422(21)00176-9
Vancouver
Miglis MG, Adler CH, Antelmi E, Arnaldi D, Baldelli L, Boeve BF, et al. Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder. The Lancet. Neurology. 2021. doi:10.1016/s1474-4422(21)00176-9. PMID: 34302789.
BibTeX
@article{miglis2021-34302789,
author = {Miglis, M. G. and Adler, C. H. and Antelmi, E. and Arnaldi, D. and Baldelli, L. and Boeve, B. F. and Cesari, M. and Dall'Antonia, I. and others},
title = {{Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder}},
journal = {The Lancet. Neurology},
year = {2021},
doi = {10.1016/s1474-4422(21)00176-9},
pmid = {34302789},
url = {https://doi.org/10.1016/s1474-4422(21)00176-9}
}
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Key findings
- These findings provide the rationale to develop reliable biomarkers that can better predict conversion to clinically manifest α-synucleinopathies.
Why it matters
This review argues that reliable biomarkers are needed to predict which patients with isolated REM sleep behaviour disorder will develop an α-synucleinopathy such as Parkinson's disease or dementia with Lewy bodies. It also states that biomarkers of progression and subtype will be needed to monitor treatment response once disease-modifying therapies exist.
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Study details
- Evidence strengthLow
How this study scored 55/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet. Neurology) |
| Journal's citation record | 3 / 4 | The Lancet Neurology: journal h-index 457 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 253 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 36.1 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 4 / 6 | Cited 15.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 3 / 4 | Cited 147 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Wolfgang Hermann Oertel: h-index 97 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Stanford University: institution h-index 2,684 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 45 institution(s) in 14 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34302789) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 55 / 100 | — |
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Read the original
- DOI: 10.1016/s1474-4422(21)00176-9
- PubMed: 34302789
- Original source →
- Free full text: The Lancet Neurology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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