GenoRisk: A polygenic risk score for Alzheimer's disease
Samuel P Dickson, Suzanne B Hendrix, Bruce L Brown, Perry G Ridge, Jessie Nicodemus-Johnson, Marci L Hardy, Allison M McKeany, Steven B Booth et al.. Alzheimer's & dementia (New York, N. Y.), 2021-09-30
Topic: Genetics and APOE
The elastic net model that included age, age x sex interaction, allelic APOE terms, and 29 additional SNPs performed the best. This model explained an additional 19% of the heritable risk compared to APOE genotype alone and achieved an area under the curve of 0.747. GenoRisk could improve the risk assessment of individuals identified for prevention studies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Dickson, S. P., Hendrix, S. B., Brown, B. L., Ridge, P. G., Nicodemus-Johnson, J., Hardy, M. L., et al. (2021). GenoRisk: A polygenic risk score for Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). https://doi.org/10.1002/trc2.12211
Vancouver
Dickson SP, Hendrix SB, Brown BL, Ridge PG, Nicodemus-Johnson J, Hardy ML, et al. GenoRisk: A polygenic risk score for Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). 2021. doi:10.1002/trc2.12211. PMID: 34621978.
BibTeX
@article{dickson2021-34621978,
author = {Dickson, Samuel P and Hendrix, Suzanne B and Brown, Bruce L and Ridge, Perry G and Nicodemus-Johnson, Jessie and Hardy, Marci L and McKeany, Allison M and Booth, Steven B and others},
title = {{GenoRisk: A polygenic risk score for Alzheimer's disease}},
journal = {Alzheimer's \& dementia (New York, N. Y.)},
year = {2021},
doi = {10.1002/trc2.12211},
pmid = {34621978},
url = {https://doi.org/10.1002/trc2.12211}
}
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Key findings
- The elastic net model that included age, age x sex interaction, allelic APOE terms, and 29 additional SNPs performed the best.
- This model explained an additional 19% of the heritable risk compared to APOE genotype alone and achieved an area under the curve of 0.747.
- GenoRisk could improve the risk assessment of individuals identified for prevention studies.
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Study details
- Study designcase-control study
- Evidence strengthModerate
How this study scored 59/100
Published in a leading specialty journal, and it is a case-control study. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 33 of the 56 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (New York, N. Y.)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 6 / 12 | A case-control study |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34621978) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 33 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 33 of the 56 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
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