Home › Research › Prevention and risk
Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds
Jessica Samuelsson, Jenna Najar, Ola Wallengren, Silke Kern, Hanna Wetterberg, Madeleine Mellqvist Fässberg, Henrik Zetterberg, Kaj Blennow et al.. European journal of nutrition, 2021-10-10
Topic: Genetics and APOE
There were interactions between the dietary patterns and APOE ε4 status in relation to incident dementia (interaction p value threshold of < 0.1), while no evidence of interactions were found between the dietary patterns and the AD-PRSs. Those with higher adherence to a healthy dietary pattern had a reduced risk of dementia among ε4 non-carriers (HR: 0.77; 95% CI: 0.61; 0.98), but not among ε4 carriers (HR: 0.86; CI: 0.63; 1.18). Those with a higher adherence to the western dietary pattern had an increased risk of dementia among ε4 carriers (HR: 1.37; 95% CI: 1.05; 1.78), while no association was observed among ε4 non-carriers (HR: 0.99; CI: 0.81; 1.21). The results of this study suggest that there is an interplay between dietary patterns and APOE ε4 status in relation to incident dementia.
Key findings
- There were interactions between the dietary patterns and APOE ε4 status in relation to incident dementia (interaction p value threshold of < 0.1), while no evidence of interactions were found between the dietary patterns and the AD-PRSs.
- Those with higher adherence to a healthy dietary pattern had a reduced risk of dementia among ε4 non-carriers (HR: 0.77; 95% CI: 0.61; 0.98), but not among ε4 carriers (HR: 0.86; CI: 0.63; 1.18).
- Those with a higher adherence to the western dietary pattern had an increased risk of dementia among ε4 carriers (HR: 1.37; 95% CI: 1.05; 1.78), while no association was observed among ε4 non-carriers (HR: 0.99; CI: 0.81; 1.21).
- The results of this study suggest that there is an interplay between dietary patterns and APOE ε4 status in relation to incident dementia.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Study designcohort study
- Effect sizeHR: 0.77; HR: 0.86; HR: 1.37
- Evidence strengthModerate
How this study scored 63/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 35 of the 56 points we could judge it on, which is 63 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European journal of nutrition) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34632537) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 35 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 35 of the 56 points we could judge it on is 63 out of 100. |
| Total | 63 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Samuelsson, J., Najar, J., Wallengren, O., Kern, S., Wetterberg, H., Fässberg, M. M., et al. (2022). Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds. European journal of nutrition. https://doi.org/10.1007/s00394-021-02688-9
Vancouver
Samuelsson J, Najar J, Wallengren O, Kern S, Wetterberg H, Fässberg MM, et al. Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds. European journal of nutrition. 2022. doi:10.1007/s00394-021-02688-9. PMID: 34632537.
BibTeX
@article{samuelsson2022-34632537,
author = {Samuelsson, Jessica and Najar, Jenna and Wallengren, Ola and Kern, Silke and Wetterberg, Hanna and Fässberg, Madeleine Mellqvist and Zetterberg, Henrik and Blennow, Kaj and others},
title = {{Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds}},
journal = {European journal of nutrition},
year = {2022},
doi = {10.1007/s00394-021-02688-9},
pmid = {34632537},
url = {https://doi.org/10.1007/s00394-021-02688-9}
}
Related studies in Prevention and risk
Also tagged “metabolic-syndrome”
304 studies in the library carry the topic tag “metabolic-syndrome”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 304 tagged studies.