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The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)
Ngandu T, Lehtisalo J, Korkki S, Solomon A, Coley N, Antikainen R, Bäckman L, Hänninen T et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021-10-20
Topic: Risk, prevention and care in population studies
Introduction Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre-specified subgroup analyses). Methods FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self-reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores. Results Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function. Discussion Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.
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APA 7th
Ngandu, T., Lehtisalo, J., Korkki, S., Solomon, A., Coley, N., Antikainen, R., et al. (2022). The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER). Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.12492
Vancouver
Ngandu T, Lehtisalo J, Korkki S, Solomon A, Coley N, Antikainen R, et al. The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER). Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022. doi:10.1002/alz.12492. PMID: 34668644.
BibTeX
@article{ngandu2022-34668644,
author = {Ngandu, T. and Lehtisalo, J. and Korkki, S. and Solomon, A. and Coley, N. and Antikainen, R. and Bäckman, L. and Hänninen, T. and others},
title = {{The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2022},
doi = {10.1002/alz.12492},
pmid = {34668644},
url = {https://doi.org/10.1002/alz.12492}
}
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Key findings
- Results Active participation was associated with better trajectories in NTB total and all cognitive subdomains.
- Improvement in lifestyle was associated with improvement in NTB total and executive function.
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Study details
- Study designrandomized controlled trial
- Participants1,260
- Evidence strengthHigh
How this study scored 80/100
Published in a leading specialty journal, and it is a randomized controlled trial. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record and institution's track record, so those were left out: it earned 49 of the 61 points we could judge it on, which is 80 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 11 / 12 | A randomized controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,260 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 1 / 2 | Randomized (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | 2 / 3 | PubMed indexes it as a multicentre study |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34668644) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 49 / 61 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 49 of the 61 points we could judge it on is 80 out of 100. |
| Total | 80 / 100 | — |
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