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Gut-brain axis: Synergistic approach
Markanday Sharma, Jyoti Prakash, Prateek Yadav, Kalpana Srivastava, Kaushik Chatterjee. Industrial psychiatry journal, 2021-10-22
Topic: Gut, metabolism and diet
Since decades, there is a change in concept of the gut-brain axis. There is differential increase in evidences focusing on the bidirectional communication between the gut microbiome and the brain. It supports existence of far-reaching model of "gut-brain axis." This axis is attaining more adherence to fields investigating biological and physiological footing of psychiatric, neuro-developmental, age-related, and neurodegenerative disorders. Many factors can change microbiota composition in early life as well as with the increasing age. Stress can affect the microbiota-gut-brain axis at every stages of life. Recent advances have involved the gut microbiota in many conditions including severe mental illness, autism, anxiety, obesity, Parkinson's disease, and Alzheimer's disease. The current studies target on elaborating the underlying mechanisms of microbiota-gut-brain axis and attempt to exemplify intervention and therapeutic strategies for neuropsychiatric disorders.
Key findings
- It supports existence of far-reaching model of "gut-brain axis." This axis is attaining more adherence to fields investigating biological and physiological footing of psychiatric, neuro-developmental, age-related, and neurodegenerative disorders.
- Many factors can change microbiota composition in early life as well as with the increasing age.
- Stress can affect the microbiota-gut-brain axis at every stages of life.
- Recent advances have involved the gut microbiota in many conditions including severe mental illness, autism, anxiety, obesity, Parkinson's disease, and Alzheimer's disease.
- The current studies target on elaborating the underlying mechanisms of microbiota-gut-brain axis and attempt to exemplify intervention and therapeutic strategies for neuropsychiatric disorders.
Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Industrial psychiatry journal) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34908715) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Sharma, M., Prakash, J., Yadav, P., Srivastava, K., & Chatterjee, K. (2021). Gut-brain axis: Synergistic approach. Industrial psychiatry journal. https://doi.org/10.4103/0972-6748.328835
Vancouver
Sharma M, Prakash J, Yadav P, Srivastava K, Chatterjee K. Gut-brain axis: Synergistic approach. Industrial psychiatry journal. 2021. doi:10.4103/0972-6748.328835. PMID: 34908715.
BibTeX
@article{sharma2021-34908715,
author = {Sharma, Markanday and Prakash, Jyoti and Yadav, Prateek and Srivastava, Kalpana and Chatterjee, Kaushik},
title = {{Gut-brain axis: Synergistic approach}},
journal = {Industrial psychiatry journal},
year = {2021},
doi = {10.4103/0972-6748.328835},
pmid = {34908715},
url = {https://doi.org/10.4103/0972-6748.328835}
}
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