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Practical application of Alzheimer's Disease Neuroimaging Initiative plasma P‐tau181 reference data to support diagnosis of Alzheimer's disease
Jemma Hazan, Duncan Alston, Nick C. Fox, Robert Howard. International Journal of Geriatric Psychiatry, 2022-01-08
Topic: Plasma and spinal-fluid biomarkers
There were significant differences in plasma p‐tau181 values between Controls and those with AD at all ages up to 85 years. There were also significant differences between AD and CI non‐AD participants up to the age of 85 years. Plasma P‐tau181 may be a useful tool in the diagnosis of AD in those clinical settings where biomarkers have traditionally been less used. P‐tau181 may be less useful as an aid to diagnosis in the very oldest‐old. Further work is needed to establish the feasibility and utility of this biomarker within dementia diagnosis services not led by Neurologists, such as UK National Health Service Memory Services.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Hazan, J., Alston, D., Fox, N. C., & Howard, R. (2022). Practical application of Alzheimer's Disease Neuroimaging Initiative plasma P‐tau181 reference data to support diagnosis of Alzheimer's disease. International Journal of Geriatric Psychiatry. https://doi.org/10.1002/gps.5670
Vancouver
Hazan J, Alston D, Fox NC, Howard R. Practical application of Alzheimer's Disease Neuroimaging Initiative plasma P‐tau181 reference data to support diagnosis of Alzheimer's disease. International Journal of Geriatric Psychiatry. 2022. doi:10.1002/gps.5670.
BibTeX
@article{hazan2022-d699c3cc,
author = {Hazan, Jemma and Alston, Duncan and Fox, Nick C. and Howard, Robert},
title = {{Practical application of Alzheimer's Disease Neuroimaging Initiative plasma P‐tau181 reference data to support diagnosis of Alzheimer's disease}},
journal = {International Journal of Geriatric Psychiatry},
year = {2022},
doi = {10.1002/gps.5670},
url = {https://doi.org/10.1002/gps.5670}
}
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Key findings
- There were significant differences in plasma p‐tau181 values between Controls and those with AD at all ages up to 85 years.
- There were also significant differences between AD and CI non‐AD participants up to the age of 85 years.
- Plasma P‐tau181 may be a useful tool in the diagnosis of AD in those clinical settings where biomarkers have traditionally been less used.
- P‐tau181 may be less useful as an aid to diagnosis in the very oldest‐old.
- Further work is needed to establish the feasibility and utility of this biomarker within dementia diagnosis services not led by Neurologists, such as UK National Health Service Memory Services.
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Study details
- Participants1,558
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International Journal of Geriatric Psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,558 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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