Home › Research › Tau biomarkers
Association of β-Amyloid Accumulation With Executive Function in Adults With Unimpaired Cognition
Tideman P, Stomrud E, Leuzy A, Mattsson-Carlgren N, Palmqvist S, Hansson O, Alzheimer's Disease Neuroimaging Initiative.. Neurology, 2022-01-12
Topic: Amyloid, tau and blood-test diagnosis
Background and objectives The neuropathologic changes underlying Alzheimer disease (AD) start before overt cognitive symptoms arise, but it is not well-known how they relate to the first subtle cognitive changes. The objective for this study was to examine the independent associations of the AD hallmarks β-amyloid (Aβ), tau, and neurodegeneration with different cognitive domains in cognitively unimpaired (CU) individuals. Methods In this cross-sectional study, CU participants from the prospective BioFINDER-2 study were included.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Tideman, P., Stomrud, E., Leuzy, A., Mattsson-Carlgren, N., Palmqvist, S., Hansson, O., et al. (2022). Association of β-Amyloid Accumulation With Executive Function in Adults With Unimpaired Cognition. Neurology. https://doi.org/10.1212/wnl.0000000000013299
Vancouver
Tideman P, Stomrud E, Leuzy A, Mattsson-Carlgren N, Palmqvist S, Hansson O, et al. Association of β-Amyloid Accumulation With Executive Function in Adults With Unimpaired Cognition. Neurology. 2022. doi:10.1212/wnl.0000000000013299. PMID: 35022305.
BibTeX
@article{tideman2022-35022305,
author = {Tideman, P. and Stomrud, E. and Leuzy, A. and Mattsson-Carlgren, N. and Palmqvist, S. and Hansson, O. and {Alzheimer's Disease Neuroimaging Initiative}},
title = {{Association of β-Amyloid Accumulation With Executive Function in Adults With Unimpaired Cognition}},
journal = {Neurology},
year = {2022},
doi = {10.1212/wnl.0000000000013299},
pmid = {35022305},
url = {https://doi.org/10.1212/wnl.0000000000013299}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- The objective for this study was to examine the independent associations of the AD hallmarks β-amyloid (Aβ), tau, and neurodegeneration with different cognitive domains in cognitively unimpaired (CU) individuals.
- Methods In this cross-sectional study, CU participants from the prospective BioFINDER-2 study were included.
- All had CSF biomarkers (Aβ42 and phosphorylated tau [p-tau]181), MRI (cortical thickness of AD-susceptible regions), Aβ-PET (neocortical uptake), tau-PET (entorhinal uptake), and cognitive test data for memory, executive function, verbal function, and visuospatial function.
- Multivariable linear regression models were performed using either CSF Aβ42, p-tau181, and cortical thickness or Aβ-PET, tau-PET, and cortical thickness as predictors of cognitive function.
Why it matters
This study examined how amyloid beta, tau, and neurodegeneration relate to different cognitive domains in cognitively unimpaired adults. It is a cross-sectional observational study and does not test any treatment, cure, or prevention.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Study designcross-sectional
- Participants217
- Evidence strengthModerate
How this study scored 60/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 58 of the 96 points we could judge it on, which is 60 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 217 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 51 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.5 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 6.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 2 / 4 | Cited 32 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 1 / 3 | Lund University: institution h-index 1,119 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35022305) |
| Free to read | 2 / 2 | Free to read |
| Points | 58 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 58 of the 96 points we could judge it on is 60 out of 100. |
| Total | 60 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 19.
Later studies that cite this one
3 studies in the alzhub library list this one in their references.
Related studies in Tau biomarkers
Also tagged “precursor”
1,339 studies in the library carry the topic tag “precursor”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,339 tagged studies.