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High lifelong cognitive reserve prolongs disability-free survival: The role of cognitive function
Xuerui Li, Wenzhe Yang, Jiao Wang, Abigail Dove, Xiuying Qi, David A Bennett, Weili Xu. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022-03-28
Topic: Brain imaging, connectivity and assessment
CR score was dose-dependently associated with disability/death (hazard ratio [HR] 0.96, 95% confidence interval [CI] 0.93-0.99). Compared to low CR, the HR (95% CI) of disability/death was 0.82 (0.70-0.95) for high CR. The median disability-free survival time was prolonged by 0.99 (95% CI 0.28-1.71) years for participants with high CR. Cognitive function mediated 35.7% of the association between CR and disability-free survival. High lifelong CR was associated with prolonged disability-free survival. Cognitive function mediates about one-third of this association. Our findings underscore the importance of CR for healthy aging.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Li, X., Yang, W., Wang, J., Dove, A., Qi, X., Bennett, D. A., et al. (2023). High lifelong cognitive reserve prolongs disability-free survival: The role of cognitive function. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.12670
Vancouver
Li X, Yang W, Wang J, Dove A, Qi X, Bennett DA, et al. High lifelong cognitive reserve prolongs disability-free survival: The role of cognitive function. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023. doi:10.1002/alz.12670. PMID: 35347843.
BibTeX
@article{li2023-35347843,
author = {Li, Xuerui and Yang, Wenzhe and Wang, Jiao and Dove, Abigail and Qi, Xiuying and Bennett, David A and Xu, Weili},
title = {{High lifelong cognitive reserve prolongs disability-free survival: The role of cognitive function}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2023},
doi = {10.1002/alz.12670},
pmid = {35347843},
url = {https://doi.org/10.1002/alz.12670}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- CR score was dose-dependently associated with disability/death (hazard ratio [HR] 0.96, 95% confidence interval [CI] 0.93-0.99).
- Compared to low CR, the HR (95% CI) of disability/death was 0.82 (0.70-0.95) for high CR.
- The median disability-free survival time was prolonged by 0.99 (95% CI 0.28-1.71) years for participants with high CR.
- Cognitive function mediated 35.7% of the association between CR and disability-free survival.
- High lifelong CR was associated with prolonged disability-free survival.
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Study details
- Effect size35.7%
- Evidence strengthLow
How this study scored 48/100
Published in a leading specialty journal. Scored zero for study design, sample size, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 27 of the 56 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35347843) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 27 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 27 of the 56 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
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