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Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study
Tai XY, Veldsman M, Lyall DM, Littlejohns TJ, Langa KM, Husain M, Ranson J, Llewellyn DJ.. The lancet. Healthy longevity, 2022-06-01
Topic: Risk, prevention and care in population studies
Background Individual cardiometabolic disorders and genetic factors are associated with an increased dementia risk; however, the relationship between dementia and cardiometabolic multimorbidity is unclear. We investigated whether cardiometabolic multimorbidity increases the risk of dementia, regardless of genetic risk, and examined for associated brain structural changes. Methods We examined health and genetic data from 203 038 UK Biobank participants of European ancestry, aged 60 years or older without dementia at baseline assessment (2006-10) and followed up until March 31, 2021, in England and Scotland and Feb 28, 2018, in Wales, as well as brain structural data in a nested imaging subsample of 12 236 participants.
Key findings
- We investigated whether cardiometabolic multimorbidity increases the risk of dementia, regardless of genetic risk, and examined for associated brain structural changes.
- Methods We examined health and genetic data from 203 038 UK Biobank participants of European ancestry, aged 60 years or older without dementia at baseline assessment (2006-10) and followed up until March 31, 2021, in England and Scotland and Feb 28, 2018, in Wales, as well as brain structural data in a nested imaging subsample of 12 236 participants.
- A cardiometabolic multimorbidity index comprising stroke, diabetes, and myocardial infarction (one point for each), and a polygenic risk score for dementia (with low, intermediate, and high risk groups) were calculated for each participant.
- The main outcome measures were incident all-cause dementia and brain structural metrics.
Why it matters
This study investigated whether cardiometabolic multimorbidity increases the risk of dementia regardless of genetic risk, and examined associated brain structural changes. It is an observational cohort study of a possible risk factor and does not test any treatment, cure, or prevention.
Study details
- Participants236
- Evidence strengthLow
How this study scored 60/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The lancet. Healthy longevity) |
| Journal's citation record | 1 / 4 | The Lancet Healthy Longevity: journal h-index 78 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 236 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 136 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 22.7 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 4 / 6 | Cited 15.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 18 other studies in this library |
| Still being cited | 3 / 4 | Cited 113 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author David J. Llewellyn: h-index 68 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Michigan: institution h-index 2,240 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 11 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35711612) |
| Free to read | 2 / 2 | Free to read |
| Total | 60 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/s2666-7568(22)00117-9
- PubMed: 35711612
- Original source →
- Free full text: The Lancet Healthy Longevity →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Tai, X. Y., Veldsman, M., Lyall, D. M., Littlejohns, T. J., Langa, K. M., Husain, M., et al. (2022). Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study. The lancet. Healthy longevity. https://doi.org/10.1016/s2666-7568(22)00117-9
Vancouver
Tai XY, Veldsman M, Lyall DM, Littlejohns TJ, Langa KM, Husain M, et al. Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study. The lancet. Healthy longevity. 2022. doi:10.1016/s2666-7568(22)00117-9. PMID: 35711612.
BibTeX
@article{tai2022-35711612,
author = {Tai, X. Y. and Veldsman, M. and Lyall, D. M. and Littlejohns, T. J. and Langa, K. M. and Husain, M. and Ranson, J. and Llewellyn, D. J.},
title = {{Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study}},
journal = {The lancet. Healthy longevity},
year = {2022},
doi = {10.1016/s2666-7568(22)00117-9},
pmid = {35711612},
url = {https://doi.org/10.1016/s2666-7568(22)00117-9}
}
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