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Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia
Mesulam MM, Coventry CA, Bigio EH, Sridhar J, Gill N, Fought AJ, Zhang H, Thompson CK et al.. Brain : a journal of neurology, 2022-06-01
Topic: Brain proteins, microglia and lab models
Comparisons of ADNC in typical amnestic versus atypical aphasic dementia and of TDP in type A versus type C revealed fundamental biological and clinical differences, suggesting that members of each pair may constitute distinct clinicopathologic entities despite identical downstream proteinopathies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Mesulam, M. M., Coventry, C. A., Bigio, E. H., Sridhar, J., Gill, N., Fought, A. J., et al. (2022). Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia. Brain : a journal of neurology. https://doi.org/10.1093/brain/awab410
Vancouver
Mesulam MM, Coventry CA, Bigio EH, Sridhar J, Gill N, Fought AJ, et al. Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia. Brain : a journal of neurology. 2022. doi:10.1093/brain/awab410. PMID: 35441216.
BibTeX
@article{mesulam2022-35441216,
author = {Mesulam, M. M. and Coventry, C. A. and Bigio, E. H. and Sridhar, J. and Gill, N. and Fought, A. J. and Zhang, H. and Thompson, C. K. and others},
title = {{Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia}},
journal = {Brain : a journal of neurology},
year = {2022},
doi = {10.1093/brain/awab410},
pmid = {35441216},
url = {https://doi.org/10.1093/brain/awab410}
}
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Key findings
- Comparisons of ADNC in typical amnestic versus atypical aphasic dementia and of TDP in type A versus type C revealed fundamental biological and clinical differences, suggesting that members of each pair may constitute distinct clinicopathologic entities despite identical downstream proteinopathies.
Why it matters
Comparing Alzheimer's disease neuropathologic change in typical amnestic versus atypical aphasic dementia, and TDP in type A versus type C, revealed fundamental biological and clinical differences suggesting each pair may be distinct clinicopathologic entities despite identical downstream proteinopathies. This is a longitudinal neuropathological study and reports no treatment, cure or prevention.
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Study details
- Study designlongitudinal study
- Participants68
- Evidence strengthModerate
How this study scored 62/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 68 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 57 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.5 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 4.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 38 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Emily Joy Rogalski: h-index 59 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Northwestern University: institution h-index 1,592 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35441216) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 62 / 100 | — |
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