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66/100

✓ Peer-reviewed alzhub usefulness score 66 out of 100. Cognitive tests and assessment

Topic: Brain imaging, connectivity and assessment

Plain-language summary

DNS-br total score and majority of the 11 DNS-br neurocognitive subdomain scores were significantly associated with FDG-PET resilience signature, PIB ratio, cerebral gray matter and white matter volume after adjusting for multiple testing. DNS-br total score predicts cognitive impairment for the 80+ individuals in the Altoida large cohort study. We identified a significant interaction between the DNS-br total score and time, indicating that participants with higher DNS-br total score or FDG-PET in the resilience signature would show less cognitive decline over time. Our findings highlight that a digital biomarker predicted cognitive functioning and change, which established biomarkers are unable to reliably do. Our findings also offer possible etiologies of MCI and AD, where education did not protect against cognitive decline.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Seixas, A. A., Rajabli, F., Pericak-Vance, M. A., Jean-Louis, G., Harms, R. L., & Tarnanas, I. (2022). Associations of digital neuro-signatures with molecular and neuroimaging measures of brain resilience: The altoida large cohort study. Frontiers in psychiatry. https://doi.org/10.3389/fpsyt.2022.899080

Vancouver

Seixas AA, Rajabli F, Pericak-Vance MA, Jean-Louis G, Harms RL, Tarnanas I. Associations of digital neuro-signatures with molecular and neuroimaging measures of brain resilience: The altoida large cohort study. Frontiers in psychiatry. 2022. doi:10.3389/fpsyt.2022.899080. PMID: 36061297.

BibTeX

@article{seixas2022-36061297,
  author  = {Seixas, Azizi A and Rajabli, Farid and Pericak-Vance, Margaret A and Jean-Louis, Girardin and Harms, Robbert L and Tarnanas, Ioannis},
  title   = {{Associations of digital neuro-signatures with molecular and neuroimaging measures of brain resilience: The altoida large cohort study}},
  journal = {Frontiers in psychiatry},
  year    = {2022},
  doi     = {10.3389/fpsyt.2022.899080},
  pmid    = {36061297},
  url     = {https://doi.org/10.3389/fpsyt.2022.899080}
}

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How to read this study

Design: this is a follow-up (cohort) study. People are observed over time and not assigned to anything, so an association can reflect other differences between groups. Look at how long follow-up lasted, how many dropped out, and whether the authors adjusted for age, education and other health conditions.
Size: the record lists 283 participants. Ask whether that is enough for the question, and who they were.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded moderate. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Moderate means the abstract mentions a cohort, case-control or longitudinal design. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

DNS-br total score and majority of the 11 DNS-br neurocognitive subdomain scores were significantly associated with FDG-PET resilience signature, PIB ratio, cerebral gray matter and white matter volume after adjusting for multiple testing.
DNS-br total score predicts cognitive impairment for the 80+ individuals in the Altoida large cohort study.
We identified a significant interaction between the DNS-br total score and time, indicating that participants with higher DNS-br total score or FDG-PET in the resilience signature would show less cognitive decline over time.
Our findings highlight that a digital biomarker predicted cognitive functioning and change, which established biomarkers are unable to reliably do.
Our findings also offer possible etiologies of MCI and AD, where education did not protect against cognitive decline.

Study details

Study designcohort study
Participants283
Evidence strengthModerate

How this study scored 66/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 37 of the 56 points we could judge it on, which is 66 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Frontiers in psychiatry)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2022 — within 6 year(s) of the newest study here
Sample size	2 / 4	283 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multicenter collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 36061297)
Free to read	— / 2	Access not recorded — left out of this score
Points	37 / 56	Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 37 of the 56 points we could judge it on is 66 out of 100.
Total	66 / 100	—

What each of these 20 components measures, and what this score is not →

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