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Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias
Sanjana Shellikeri, Sunghye Cho, Katheryn A Q Cousins, Mark Liberman, Erica Howard, Yvonne Balganorth, Daniel Weintraub, Meredith Spindler et al.. Parkinsonism & related disorders, 2022-08-06
Topic: Brain imaging, connectivity and assessment
Age of acquisition of nouns (p = 0.034, |d| = 0.77) and lexical density (p = 0.0064, |d| = 0.72) were reduced in SYN + AD, and together showed excellent discrimination for SYN + AD vs. SYN-AD (95% sensitivity, 66% specificity; AUC = 0.82). Lower lexical density was related to higher CSF t-Tau levels (R = -0.41, p = 0.0021). Clinically-diagnosed PDD vs. DLB did not differ on any speech features. AD co-pathology may result in a deviant natural speech profile in LBD characterized by specific lexical-semantic impairments, not detectable by clinical disorder diagnosis. Our study demonstrates the potential of automated digital speech analytics as a screening tool for underlying AD co-pathology in LBD.
Key findings
- Age of acquisition of nouns (p = 0.034, |d| = 0.77) and lexical density (p = 0.0064, |d| = 0.72) were reduced in SYN + AD, and together showed excellent discrimination for SYN + AD vs.
- SYN-AD (95% sensitivity, 66% specificity; AUC = 0.82).
- Lower lexical density was related to higher CSF t-Tau levels (R = -0.41, p = 0.0021).
- DLB did not differ on any speech features.
- AD co-pathology may result in a deviant natural speech profile in LBD characterized by specific lexical-semantic impairments, not detectable by clinical disorder diagnosis.
Study details
- Effect sizeAUC = 0.82
- Evidence strengthModerate
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Parkinsonism & related disorders) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35985146) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Shellikeri, S., Cho, S., Cousins, K. A. Q., Liberman, M., Howard, E., Balganorth, Y., et al. (2022). Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias. Parkinsonism & related disorders. https://doi.org/10.1016/j.parkreldis.2022.07.023
Vancouver
Shellikeri S, Cho S, Cousins KAQ, Liberman M, Howard E, Balganorth Y, et al. Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias. Parkinsonism & related disorders. 2022. doi:10.1016/j.parkreldis.2022.07.023. PMID: 35985146.
BibTeX
@article{shellikeri2022-35985146,
author = {Shellikeri, Sanjana and Cho, Sunghye and Cousins, Katheryn A Q and Liberman, Mark and Howard, Erica and Balganorth, Yvonne and Weintraub, Daniel and Spindler, Meredith and others},
title = {{Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias}},
journal = {Parkinsonism \& related disorders},
year = {2022},
doi = {10.1016/j.parkreldis.2022.07.023},
pmid = {35985146},
url = {https://doi.org/10.1016/j.parkreldis.2022.07.023}
}
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