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Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment
Williamson J, Yabluchanskiy A, Mukli P, Wu DH, Sonntag W, Ciro C, Yang Y.. Frontiers in aging neuroscience, 2022-08-10
Topic: Risk, prevention and care in population studies
Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer's Disease (AD). Prior research shows that females are more impacted by MCI than males. On average females have a greater incidence rate of any dementia and current evidence suggests that they suffer greater cognitive deterioration than males in the same disease stage.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Williamson, J., Yabluchanskiy, A., Mukli, P., Wu, D. H., Sonntag, W., Ciro, C., et al. (2022). Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment. Frontiers in aging neuroscience. https://doi.org/10.3389/fnagi.2022.959394
Vancouver
Williamson J, Yabluchanskiy A, Mukli P, Wu DH, Sonntag W, Ciro C, et al. Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment. Frontiers in aging neuroscience. 2022. doi:10.3389/fnagi.2022.959394. PMID: 36034134.
BibTeX
@article{williamson2022-36034134,
author = {Williamson, J. and Yabluchanskiy, A. and Mukli, P. and Wu, D. H. and Sonntag, W. and Ciro, C. and Yang, Y.},
title = {{Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment}},
journal = {Frontiers in aging neuroscience},
year = {2022},
doi = {10.3389/fnagi.2022.959394},
pmid = {36034134},
url = {https://doi.org/10.3389/fnagi.2022.959394}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Prior research shows that females are more impacted by MCI than males.
- On average females have a greater incidence rate of any dementia and current evidence suggests that they suffer greater cognitive deterioration than males in the same disease stage.
- Recent research has linked these sex differences to neuroimaging markers of brain pathology, such as hippocampal volumes.
- Specifically, the rate of hippocampal atrophy affects the progression of AD in females more than males.
Why it matters
This study looked at sex differences in how the hippocampus connects to other brain regions in people with mild cognitive impairment. It is about understanding why females may be more affected, and does not test any treatment, cure, or prevention.
Study details
- Participants40
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in aging neuroscience) |
| Journal's citation record | 2 / 4 | Frontiers in Aging Neuroscience: journal h-index 174 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 40 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 43 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.2 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 5.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 33 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Yuan Yang: h-index 28 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Northwestern University: institution h-index 1,592 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36034134) |
| Free to read | 2 / 2 | Free to read |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fnagi.2022.959394
- PubMed: 36034134
- Original source →
- Free full text: Frontiers in Aging Neuroscience →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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Referenced by this study and also in the alzhub library, so you can read them here.
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