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58/100

✓ Peer-reviewed alzhub usefulness score 58 out of 100. Inflammation and the immune system

Topic: Amyloid, tau and blood-test diagnosis

Plain-language summary

Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dementia. AD is highly heritable, with heritability estimates of ∼70% from twin studies. Progressively larger genome-wide association studies (GWAS) have continued to expand our knowledge of AD/dementia genetic architecture.

What this study adds

Evidence grade: Low

This is a narrative review. This review reports that Alzheimer's disease is highly heritable, with heritability estimated at about 70% from twin studies, and that larger genetic studies have greatly increased the number of known disease susceptibility loci. It does not describe a treatment or cure; it indicates that genetic research is expanding knowledge of who may be at risk and why.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Andrews, S. J., Renton, A. E., Fulton-Howard, B., Podlesny-Drabiniok, A., Marcora, E., & Goate, A. M. (2023). The complex genetic architecture of Alzheimer's disease: novel insights and future directions. EBioMedicine. https://doi.org/10.1016/j.ebiom.2023.104511

Vancouver

Andrews SJ, Renton AE, Fulton-Howard B, Podlesny-Drabiniok A, Marcora E, Goate AM. The complex genetic architecture of Alzheimer's disease: novel insights and future directions. EBioMedicine. 2023. doi:10.1016/j.ebiom.2023.104511. PMID: 36907103.

BibTeX

@article{andrews2023-36907103,
  author  = {Andrews, S. J. and Renton, A. E. and Fulton-Howard, B. and Podlesny-Drabiniok, A. and Marcora, E. and Goate, A. M.},
  title   = {{The complex genetic architecture of Alzheimer's disease: novel insights and future directions}},
  journal = {EBioMedicine},
  year    = {2023},
  doi     = {10.1016/j.ebiom.2023.104511},
  pmid    = {36907103},
  url     = {https://doi.org/10.1016/j.ebiom.2023.104511}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

How to read this study

Design: this is a narrative review. It summarises a field without a fixed search method, so it shows how authors read the evidence rather than measuring it. Use it to find the primary studies, not as a result in itself.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

New to reading papers? Six questions to ask of any Alzheimer’s study · how we score.

Key findings

AD is highly heritable, with heritability estimates of ∼70% from twin studies.
Progressively larger genome-wide association studies (GWAS) have continued to expand our knowledge of AD/dementia genetic architecture.
Until recently these efforts had identified 39 disease susceptibility loci in European ancestry populations.
Recent developments Two new AD/dementia GWAS have dramatically expanded the sample sizes and the number of disease susceptibility loci.

Why it matters

This review reports that Alzheimer's disease is highly heritable, with heritability estimated at about 70% from twin studies, and that larger genetic studies have greatly increased the number of known disease susceptibility loci. It does not describe a treatment or cure; it indicates that genetic research is expanding knowledge of who may be at risk and why.

Study details

Evidence strengthLow

How this study scored 58/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (EBioMedicine)
Journal's citation record	2 / 4	EBioMedicine: journal h-index 181 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2023 — within 6 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 377 times (OpenAlex, 2026-10-10)
Citations per year	5 / 5	75.4 citations a year over 5 year(s) since 2023
Impact for its field and year	6 / 6	Cited 55.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 28 other studies in this library
Still being cited	4 / 4	Cited 352 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Alison Goate: h-index 156 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California, San Francisco: institution h-index 1,915 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 36907103)
Free to read	2 / 2	Free to read
Total	58 / 100	—

What each of these 20 components measures, and what this score is not →

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