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A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status
Robin Ziyue Zhou, Davide Liborio Vetrano, Giulia Grande, Frida Duell, Linus Jönsson, Erika J Laukka, Claudia Fredolini, Bengt Winblad et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023-04-12
Topic: Plasma and spinal-fluid biomarkers
Bisecting N-acetylglucosamine correlated with tau levels (p < 0.0001). Individuals with an intermediate tau/bisecting N-acetylglucosamine ratio had elevated AD risk (hazard ratio = 2.06, 95% confidence interval [CI]: 1.18-3.6). Moreover, a combined model including tau/bisecting N-acetylglucosamine ratio, apolipoprotein E (APOE) ε4 status, and Mini-Mental State Examination score predicted future AD (area under the curve = 0.81, 95% CI: 0.68-0.93). Bisecting N-acetylglucosamine in combination with tau is a valuable blood biomarker for predicting AD.
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APA 7th
Zhou, R. Z., Vetrano, D. L., Grande, G., Duell, F., Jönsson, L., Laukka, E. J., et al. (2023). A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.13024
Vancouver
Zhou RZ, Vetrano DL, Grande G, Duell F, Jönsson L, Laukka EJ, et al. A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023. doi:10.1002/alz.13024. PMID: 37042462.
BibTeX
@article{zhou2023-37042462,
author = {Zhou, Robin Ziyue and Vetrano, Davide Liborio and Grande, Giulia and Duell, Frida and Jönsson, Linus and Laukka, Erika J and Fredolini, Claudia and Winblad, Bengt and others},
title = {{A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2023},
doi = {10.1002/alz.13024},
pmid = {37042462},
url = {https://doi.org/10.1002/alz.13024}
}
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Key findings
- Bisecting N-acetylglucosamine correlated with tau levels (p < 0.0001).
- Individuals with an intermediate tau/bisecting N-acetylglucosamine ratio had elevated AD risk (hazard ratio = 2.06, 95% confidence interval [CI]: 1.18-3.6).
- Moreover, a combined model including tau/bisecting N-acetylglucosamine ratio, apolipoprotein E (APOE) ε4 status, and Mini-Mental State Examination score predicted future AD (area under the curve = 0.81, 95% CI: 0.68-0.93).
- Bisecting N-acetylglucosamine in combination with tau is a valuable blood biomarker for predicting AD.
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Study details
- Study designretrospective cohort
- Participants233
- Evidence strengthModerate
How this study scored 70/100
Published in a leading specialty journal, and it is a retrospective cohort study, reconstructed from past records. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 39 of the 56 points we could judge it on, which is 70 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A retrospective cohort study, reconstructed from past records |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 233 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37042462) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 39 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 39 of the 56 points we could judge it on is 70 out of 100. |
| Total | 70 / 100 | — |
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