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Stem cell-conditioned medium is a promising treatment for Alzheimer's disease
Alidoust L, Akhoondian M, Atefi AH, Keivanlou MH, Hedayati Ch M, Jafari A.. Behavioural brain research, 2023-06-11
Topic: Amyloid, tau and blood-test diagnosis
Background and aim Alzheimer's disease (AD), a prevalent progressive neurodegenerative disease, is mainly characterized by dementia, memory loss, and cognitive disorder. Rising research was performed to develop pharmacological or non-pharmacological approaches to treat or improve AD complications. Mesenchymal stem cells (MSCs) are stromal cells that can self-renew and exhibit multilineage differentiation. Recent evidence suggested that some of the therapeutic effects of MSCs are mediated by the secreted paracrine factors. These paracrine factors, called MSC- conditioned medium (MSC-CM), may stimulate endogenous repair, promote angio- and artery genesis, and reduce apoptosis through paracrine mechanisms. The current study aims to systematically review the advantages of MSC-CM to the development of research and therapeutic concepts for AD management. Material and methods The present systematic review was performed using PubMed, Web of Science, and Scopus from April 2020 to May 2022 following the "Preferred Reporting Items for Systematic Reviews" (PRISMA) guidelines. The keywords, including "Conditioned medium OR Conditioned media OR Stem cell therapy" AND "Alzheimer's," was searched, and finally, 13 papers were extracted. Results The obtained data revealed that MSC-CMs might positively affect neurodegenerative diseases prognosis, especially AD, through various mechanisms, including a decrease in neuro-inflammation, reduction of oxidative stress and Aβ formation, modulation of Microglia function and count, reduction of apoptosis, induction of synaptogenesis and neurogenesis. Also, the results showed that MSC-CM administration could significantly improve cognitive and memory function, increase the expression of neurotrophic factors, decrease the production of pro-inflammatory cytokines, improve mitochondrial function, reduce cytotoxicity, and increase neurotransmitter levels. Conclusion While inhibiting the induction of neuroinflammation could be considered the first therapeutic effect of CMs, the prevention of apoptosis could be regarded as the most crucial effect of CMs on AD improvement.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Alidoust, L., Akhoondian, M., Atefi, A. H., Keivanlou, M. H., Hedayati Ch, M., & Jafari, A. (2023). Stem cell-conditioned medium is a promising treatment for Alzheimer's disease. Behavioural brain research. https://doi.org/10.1016/j.bbr.2023.114543
Vancouver
Alidoust L, Akhoondian M, Atefi AH, Keivanlou MH, Hedayati Ch M, Jafari A. Stem cell-conditioned medium is a promising treatment for Alzheimer's disease. Behavioural brain research. 2023. doi:10.1016/j.bbr.2023.114543. PMID: 37311523.
BibTeX
@article{alidoust2023-37311523,
author = {Alidoust, L. and Akhoondian, M. and Atefi, A. H. and Keivanlou, M. H. and Hedayati Ch, M. and Jafari, A.},
title = {{Stem cell-conditioned medium is a promising treatment for Alzheimer's disease}},
journal = {Behavioural brain research},
year = {2023},
doi = {10.1016/j.bbr.2023.114543},
pmid = {37311523},
url = {https://doi.org/10.1016/j.bbr.2023.114543}
}
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Key findings
- Recent evidence suggested that some of the therapeutic effects of MSCs are mediated by the secreted paracrine factors.
- Results The obtained data revealed that MSC-CMs might positively affect neurodegenerative diseases prognosis, especially AD, through various mechanisms, including a decrease in neuro-inflammation, reduction of oxidative stress and Aβ formation, modulation of Microglia function and count, reduction of apoptosis, induction of synaptogenesis and neurogenesis.
- Also, the results showed that MSC-CM administration could significantly improve cognitive and memory function, increase the expression of neurotrophic factors, decrease the production of pro-inflammatory cytokines, improve mitochondrial function, reduce cytotoxicity, and increase neurotransmitter levels.
Why it matters
This review of 13 papers looked at conditioned medium, the mix of substances released by mesenchymal stem cells, as a possible Alzheimer's treatment. The studies suggested it might reduce inflammation, oxidative stress and Aβ formation, and could improve memory and cognitive function. The authors see reducing inflammation and preventing cell death as its key effects, but the record does not establish it as a proven treatment for patients.
Study details
- Study designsystematic review
- Evidence strengthHigh
How this study scored 50/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size, effect reported and studied in people because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Behavioural brain research) |
| Journal's citation record | 3 / 4 | Behavioural Brain Research: journal h-index 252 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 2 / 7 | Cited 11 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.2 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 2 / 6 | Cited 1.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Adele Jafari: h-index 10 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University of Guilan: institution h-index 182 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37311523) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
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