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Altered within- and between-network functional connectivity in atypical Alzheimer's disease
Neha Atulkumar Singh, Peter R Martin, Jonathan Graff-Radford, Irene Sintini, Mary M Machulda, Joseph R Duffy, Jeffrey L Gunter, Hugo Botha et al.. Brain communications, 2023-06-14
Topic: Brain imaging, connectivity and assessment
Reduced within-network connectivity was observed in the language network in both phenotypes, with stronger evidence of reductions in logopenic progressive aphasia compared to controls. Only posterior cortical atrophy showed reduced within-network connectivity in the visual network compared to controls. No significant change was noted in the memory network, but a slight increase in the salience within-network connectivity was seen in both phenotypes compared to controls. Between-network analysis in posterior cortical atrophy showed evidence of reduced visual-to-language network connectivity, with reduced visual-to-salience network connectivity, compared to controls. An increase in visual-to-default mode network connectivity was noted in posterior cortical atrophy compared to controls. Between-network analysis in logopenic progressive aphasia showed evidence of reduced language-to-visual network connectivity and an increase in language-to-salience network connectivity compared to controls. Findings from the voxel-level and network-level analysis were in line with the Bayesian hierarchical linear model analysis, showing reduced connectivity in the dominant network based on diagnosis and more crosstalk between networks in general compared to controls. The atypical Alzheimer's disease phenotypes were associated with disruptions in connectivity, both within and between brain networks.
Key findings
- Reduced within-network connectivity was observed in the language network in both phenotypes, with stronger evidence of reductions in logopenic progressive aphasia compared to controls.
- Only posterior cortical atrophy showed reduced within-network connectivity in the visual network compared to controls.
- No significant change was noted in the memory network, but a slight increase in the salience within-network connectivity was seen in both phenotypes compared to controls.
- Between-network analysis in posterior cortical atrophy showed evidence of reduced visual-to-language network connectivity, with reduced visual-to-salience network connectivity, compared to controls.
- An increase in visual-to-default mode network connectivity was noted in posterior cortical atrophy compared to controls.
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Study details
- Participants144
- Evidence strengthModerate
How this study scored 57/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 32 of the 56 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain communications) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 144 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37434879) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 32 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 32 of the 56 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Singh, N. A., Martin, P. R., Graff-Radford, J., Sintini, I., Machulda, M. M., Duffy, J. R., et al. (2023). Altered within- and between-network functional connectivity in atypical Alzheimer's disease. Brain communications. https://doi.org/10.1093/braincomms/fcad184
Vancouver
Singh NA, Martin PR, Graff-Radford J, Sintini I, Machulda MM, Duffy JR, et al. Altered within- and between-network functional connectivity in atypical Alzheimer's disease. Brain communications. 2023. doi:10.1093/braincomms/fcad184. PMID: 37434879.
BibTeX
@article{singh2023-37434879,
author = {Singh, Neha Atulkumar and Martin, Peter R and Graff-Radford, Jonathan and Sintini, Irene and Machulda, Mary M and Duffy, Joseph R and Gunter, Jeffrey L and Botha, Hugo and others},
title = {{Altered within- and between-network functional connectivity in atypical Alzheimer's disease}},
journal = {Brain communications},
year = {2023},
doi = {10.1093/braincomms/fcad184},
pmid = {37434879},
url = {https://doi.org/10.1093/braincomms/fcad184}
}