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59/100

✓ Peer-reviewed alzhub usefulness score 59 out of 100. Disparities

Topic: Health services, long-term care and technology

After ≤15 years, 5,491 all-cause dementia cases were diagnosed. Racial minority status (RACE_ETHN, Non-White vs. White) increased dementia risk by 24% (HR = 1.24, 95% CI: 1.07-1.45, P = 0.005), an association attenuated by socio-economic status (SES), (HR = 1.12, 95% CI: 0.96-1.31). Total race-dementia effect was mediated through both SES and Life's Essential 8 lifestyle sub-score (LE8LIFESTYLE), combining diet, smoking, physical activity, and sleep factors. SES was inversely related to dementia risk (HR = 0.69, 95% CI: 0.67, 0.72, P < 0.001). Pathways explaining excess dementia risk among racial minorities included 'RACE_ETHN(-) → SES(-) → DEMENTIA', 'RACE_ETHN(-) → SES(-) → Poor cognitive performance, COGN(+) → DEMENTIA' and 'RACE_ETHN(-) → SES(+) → LE8LIFESTYLE(-) → DEMENTIA'. Pending future interventions, lifestyle factors including diet, smoking, physical activity, and sleep are crucial for reducing racial and socio-economic disparities in dementia.

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APA 7th

Beydoun, M. A., Beydoun, H. A., Fanelli-Kuczmarski, M. T., Weiss, J., Georgescu, M. F., Meirelles, O., et al. (2023). Pathways explaining racial/ethnic and socio-economic disparities in dementia incidence: the UK Biobank study. Aging. https://doi.org/10.18632/aging.205058

Vancouver

Beydoun MA, Beydoun HA, Fanelli-Kuczmarski MT, Weiss J, Georgescu MF, Meirelles O, et al. Pathways explaining racial/ethnic and socio-economic disparities in dementia incidence: the UK Biobank study. Aging. 2023. doi:10.18632/aging.205058. PMID: 37751591.

BibTeX

@article{beydoun2023-37751591,
  author  = {Beydoun, May A and Beydoun, Hind A and Fanelli-Kuczmarski, Marie T and Weiss, Jordan and Georgescu, Michael F and Meirelles, Osorio and Lyall, Donald M and Evans, Michele K and others},
  title   = {{Pathways explaining racial/ethnic and socio-economic disparities in dementia incidence: the UK Biobank study}},
  journal = {Aging},
  year    = {2023},
  doi     = {10.18632/aging.205058},
  pmid    = {37751591},
  url     = {https://doi.org/10.18632/aging.205058}
}

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Key findings

After ≤15 years, 5,491 all-cause dementia cases were diagnosed.
Racial minority status (RACE_ETHN, Non-White vs.
White) increased dementia risk by 24% (HR = 1.24, 95% CI: 1.07-1.45, P = 0.005), an association attenuated by socio-economic status (SES), (HR = 1.12, 95% CI: 0.96-1.31).
Total race-dementia effect was mediated through both SES and Life's Essential 8 lifestyle sub-score (LE8LIFESTYLE), combining diet, smoking, physical activity, and sleep factors.
SES was inversely related to dementia risk (HR = 0.69, 95% CI: 0.67, 0.72, P < 0.001).

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Study details

Participants323,483
Effect size3.6%; HR = 1.24; HR = 1.12
Evidence strengthLow

How this study scored 59/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 33 of the 56 points we could judge it on, which is 59 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Aging)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2023 — within 6 year(s) of the newest study here
Sample size	4 / 4	323,483 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multi-centre collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 37751591)
Free to read	— / 2	Access not recorded — left out of this score
Points	33 / 56	Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 33 of the 56 points we could judge it on is 59 out of 100.
Total	59 / 100	—

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