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Associations between multimorbidity burden and Alzheimer's pathology in older adults without dementia: the CABLE study
Qiaolifan Aerqin, Xiao-Tong Chen, Ya-Nan Ou, Ya-Hui Ma, Ya-Ru Zhang, He-Ying Hu, Lan Tan, Jin-Tai Yu. Neurobiology of aging, 2023-09-27
Topic: Plasma and spinal-fluid biomarkers
Studies have shown that multimorbidity may be associated with the Alzheimer's disease (AD) stages, but it has not been fully characterized in patients without dementia. A total of 1402 Han Chinese older adults without dementia from Chinese Alzheimer's Biomarker and LifestylE (CABLE) study were included and grouped according to their multimorbidity patterns, defined by the number of chronic disorders and cluster analysis. Multivariable linear regression models were used to detect the associations with AD-related cerebrospinal fluid (CSF) biomarkers. Multimorbidity and severe multimorbidity (≥4 chronic conditions) were significantly associated with CSF amyloid and tau levels (pFDR < 0.05). Metabolic patterns were significantly associated with higher levels of CSF Aβ40 (β = 0.159, pFDR = 0.036) and tau (P-tau: β = 0.132, pFDR = 0.035; T-tau: β = 0.126, pFDR = 0.035). The above associations were only significant in the cognitively normal (CN) group. Multimorbidity was associated with brain AD pathology before any symptomatic evidence of cognitive impairment. Identifying such high-risk groups might allow tailored interventions for AD prevention.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Aerqin, Q., Chen, X.-T., Ou, Y.-N., Ma, Y.-H., Zhang, Y.-R., Hu, H.-Y., et al. (2024). Associations between multimorbidity burden and Alzheimer's pathology in older adults without dementia: the CABLE study. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2023.09.014
Vancouver
Aerqin Q, Chen X.-T, Ou Y.-N, Ma Y.-H, Zhang Y.-R, Hu H.-Y, et al. Associations between multimorbidity burden and Alzheimer's pathology in older adults without dementia: the CABLE study. Neurobiology of aging. 2024. doi:10.1016/j.neurobiolaging.2023.09.014. PMID: 37950963.
BibTeX
@article{aerqin2024-37950963,
author = {Aerqin, Qiaolifan and Chen, Xiao-Tong and Ou, Ya-Nan and Ma, Ya-Hui and Zhang, Ya-Ru and Hu, He-Ying and Tan, Lan and Yu, Jin-Tai},
title = {{Associations between multimorbidity burden and Alzheimer's pathology in older adults without dementia: the CABLE study}},
journal = {Neurobiology of aging},
year = {2024},
doi = {10.1016/j.neurobiolaging.2023.09.014},
pmid = {37950963},
url = {https://doi.org/10.1016/j.neurobiolaging.2023.09.014}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Studies have shown that multimorbidity may be associated with the Alzheimer's disease (AD) stages, but it has not been fully characterized in patients without dementia.
- Multimorbidity and severe multimorbidity (≥4 chronic conditions) were significantly associated with CSF amyloid and tau levels (pFDR < 0.05).
- Metabolic patterns were significantly associated with higher levels of CSF Aβ40 (β = 0.159, pFDR = 0.036) and tau (P-tau: β = 0.132, pFDR = 0.035; T-tau: β = 0.126, pFDR = 0.035).
- The above associations were only significant in the cognitively normal (CN) group.
- Multimorbidity was associated with brain AD pathology before any symptomatic evidence of cognitive impairment.
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Study details
- Participants1,402
- Evidence strengthLow
How this study scored 54/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 30 of the 56 points we could judge it on, which is 54 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,402 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37950963) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 30 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 30 of the 56 points we could judge it on is 54 out of 100. |
| Total | 54 / 100 | — |
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