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Vascular risk, gait, behavioral, and plasma indicators of VCID
Sheelakumari Raghavan, Scott A Przybelski, Timothy G Lesnick, Angela J Fought, Robert I Reid, Robel K Gebre, B Gwen Windham, Alicia Algeciras-Schimnich et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023-11-06
Topic: Brain imaging, connectivity and assessment
VRFs and gait were associated with diffusion changes even in low age strata. All measures (VRFs, gait, behavioral, plasma GFAP, plasma NfL) were associated with white matter hyperintensities (WMHs) but mainly in intermediate and high age strata. Non-imaging indicators of VCID were related to WM damage and may aid in screening participants and assessing outcomes for VCID. HIGHLIGHTS: Non-imaging indicators of VCID can aid in prediction of MRI-measured WM damage but their importance differed by age. Vascular risk and gait measures were associated with early VCID changes measured using diffusion MRI. Plasma markers explained variability in WMH across age strata. Most non-imaging measures explained variability in WMH and vascular WM scores in intermediate and older age groups. The framework developed here can be used to evaluate new non-imaging VCID indicators proposed in the future.
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APA 7th
Raghavan, S., Przybelski, S. A., Lesnick, T. G., Fought, A. J., Reid, R. I., Gebre, R. K., et al. (2024). Vascular risk, gait, behavioral, and plasma indicators of VCID. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.13540
Vancouver
Raghavan S, Przybelski SA, Lesnick TG, Fought AJ, Reid RI, Gebre RK, et al. Vascular risk, gait, behavioral, and plasma indicators of VCID. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. doi:10.1002/alz.13540. PMID: 37932910.
BibTeX
@article{raghavan2024-37932910,
author = {Raghavan, Sheelakumari and Przybelski, Scott A and Lesnick, Timothy G and Fought, Angela J and Reid, Robert I and Gebre, Robel K and Windham, B Gwen and Algeciras-Schimnich, Alicia and others},
title = {{Vascular risk, gait, behavioral, and plasma indicators of VCID}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2024},
doi = {10.1002/alz.13540},
pmid = {37932910},
url = {https://doi.org/10.1002/alz.13540}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- VRFs and gait were associated with diffusion changes even in low age strata.
- All measures (VRFs, gait, behavioral, plasma GFAP, plasma NfL) were associated with white matter hyperintensities (WMHs) but mainly in intermediate and high age strata.
- Non-imaging indicators of VCID were related to WM damage and may aid in screening participants and assessing outcomes for VCID.
- HIGHLIGHTS: Non-imaging indicators of VCID can aid in prediction of MRI-measured WM damage but their importance differed by age.
- Vascular risk and gait measures were associated with early VCID changes measured using diffusion MRI.
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Study details
- Participants745
- Evidence strengthLow
How this study scored 55/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 31 of the 56 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 745 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37932910) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 31 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 31 of the 56 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
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