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TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells
Huang P, Zhang Z, Zhang P, Feng J, Xie J, Zheng Y, Liang X, Zhu B et al.. Molecular neurobiology, 2023-11-02
Topic: Brain proteins, microglia and lab models
Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD). Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective effects in PD by regulating the phenotype of microglia. Recent studies suggest that TREM2 regulates high glucose-induced microglial inflammation through the NLRP3 signaling pathway.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Huang, P., Zhang, Z., Zhang, P., Feng, J., Xie, J., Zheng, Y., et al. (2024). TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells. Molecular neurobiology. https://doi.org/10.1007/s12035-023-03713-0
Vancouver
Huang P, Zhang Z, Zhang P, Feng J, Xie J, Zheng Y, et al. TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells. Molecular neurobiology. 2024. doi:10.1007/s12035-023-03713-0. PMID: 37917301.
BibTeX
@article{huang2024-37917301,
author = {Huang, P. and Zhang, Z. and Zhang, P. and Feng, J. and Xie, J. and Zheng, Y. and Liang, X. and Zhu, B. and others},
title = {{TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells}},
journal = {Molecular neurobiology},
year = {2024},
doi = {10.1007/s12035-023-03713-0},
pmid = {37917301},
url = {https://doi.org/10.1007/s12035-023-03713-0}
}
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Key findings
- Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective effects in PD by regulating the phenotype of microglia.
- Recent studies suggest that TREM2 regulates high glucose-induced microglial inflammation through the NLRP3 signaling pathway.
- This study aimed to investigate the effect of TREM2 on NLRP3 inflammasome activation and neuroinflammation in PD.
- Mice were injected with AAV-TREM2-shRNA into both sides of the substantia nigra using a stereotactic injection method, followed by intraperitoneal injection of MPTP to establish chronic PD mouse model.
Why it matters
In mice and cells modeling Parkinson's disease, loss of TREM2 worsened activation of the NLRP3 inflammasome and a form of cell death called pyroptosis. This is animal and cell research on Parkinson's disease and does not directly inform Alzheimer's treatment, cure or prevention.
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Study details
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Molecular neurobiology) |
| Journal's citation record | 2 / 4 | Molecular Neurobiology: journal h-index 176 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mice”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 109 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 27.2 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 4 / 6 | Cited 9.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 3 / 4 | Cited 109 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Yuhu Zhang: h-index 34 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | South China University of Technology: institution h-index 608 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37917301) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1007/s12035-023-03713-0
- PubMed: 37917301
- Original source →
- Free full text: Molecular Neurobiology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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