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Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis Patients
Matthew R Brier, Suzanne E Schindler, Amber Salter, Dana Perantie, Nicole Shelley, Bradley Judge, Sarah Keefe, Kristopher M Kirmess et al.. Annals of neurology, 2024-07-04
Topic: Plasma and spinal-fluid biomarkers
The life expectancy of people with multiple sclerosis (MS) has increased, yet we have noted that development of a typical Alzheimer disease dementia syndrome is uncommon. We hypothesized that Alzheimer disease pathology is uncommon in MS patients. In 100 MS patients, the rate of amyloid-β plasma biomarker positivity was approximately half the rate in 300 non-MS controls matched on age, sex, apolipoprotein E proteotype, and cognitive status. Interestingly, most MS patients who did have amyloid-β pathology had features atypical for MS at diagnosis. These results support that MS is associated with reduced Alzheimer disease risk, and suggest new avenues of research. ANN NEUROL 2024;96:453-459.
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APA 7th
Brier, M. R., Schindler, S. E., Salter, A., Perantie, D., Shelley, N., Judge, B., et al. (2024). Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis Patients. Annals of neurology. https://doi.org/10.1002/ana.27027
Vancouver
Brier MR, Schindler SE, Salter A, Perantie D, Shelley N, Judge B, et al. Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis Patients. Annals of neurology. 2024. doi:10.1002/ana.27027. PMID: 38963256.
BibTeX
@article{brier2024-38963256,
author = {Brier, Matthew R and Schindler, Suzanne E and Salter, Amber and Perantie, Dana and Shelley, Nicole and Judge, Bradley and Keefe, Sarah and Kirmess, Kristopher M and others},
title = {{Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis Patients}},
journal = {Annals of neurology},
year = {2024},
doi = {10.1002/ana.27027},
pmid = {38963256},
url = {https://doi.org/10.1002/ana.27027}
}
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Key findings
- These results support that MS is associated with reduced Alzheimer disease risk, and suggest new avenues of research.
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Study details
- Evidence strengthLow
How this study scored 46/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 26 of the 56 points we could judge it on, which is 46 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38963256) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 26 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 26 of the 56 points we could judge it on is 46 out of 100. |
| Total | 46 / 100 | — |
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