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Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals
Chengjie Xiong, Jingqin Luo, David A Wolk, Leslie M Shaw, Erik D Roberson, Charles F Murchison, Rachel L Henson, Tammie L S Benzinger et al.. Nature communications, 2024-07-02
Topic: Plasma and spinal-fluid biomarkers
Blood-based biomarkers of Alzheimer disease (AD) may facilitate testing of historically under-represented groups. The Study of Race to Understand Alzheimer Biomarkers (SORTOUT-AB) is a multi-center longitudinal study to compare AD biomarkers in participants who identify their race as either Black or white. Plasma samples from 324 Black and 1,547 white participants underwent analysis with C2N Diagnostics' PrecivityAD test for Aβ42 and Aβ40. Compared to white individuals, Black individuals had higher average plasma Aβ42/40 levels at baseline, consistent with a lower average level of amyloid pathology. Interestingly, this difference resulted from lower average levels of plasma Aβ40 in Black participants. Despite the differences, Black and white individuals had similar longitudinal rates of change in Aβ42/40, consistent with a similar rate of amyloid accumulation. Our results agree with multiple recent studies demonstrating a lower prevalence of amyloid pathology in Black individuals, and additionally suggest that amyloid accumulates consistently across both groups.
Key findings
- Compared to white individuals, Black individuals had higher average plasma Aβ42/40 levels at baseline, consistent with a lower average level of amyloid pathology.
- Our results agree with multiple recent studies demonstrating a lower prevalence of amyloid pathology in Black individuals, and additionally suggest that amyloid accumulates consistently across both groups.
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Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 63/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and free to read, so those were left out: it earned 37 of the 59 points we could judge it on, which is 63 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Nature communications) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 2 / 3 | PubMed indexes it as a multicentre study |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38956096) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 37 / 59 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 37 of the 59 points we could judge it on is 63 out of 100. |
| Total | 63 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Xiong, C., Luo, J., Wolk, D. A., Shaw, L. M., Roberson, E. D., Murchison, C. F., et al. (2024). Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals. Nature communications. https://doi.org/10.1038/s41467-024-49859-w
Vancouver
Xiong C, Luo J, Wolk DA, Shaw LM, Roberson ED, Murchison CF, et al. Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals. Nature communications. 2024. doi:10.1038/s41467-024-49859-w. PMID: 38956096.
BibTeX
@article{xiong2024-38956096,
author = {Xiong, Chengjie and Luo, Jingqin and Wolk, David A and Shaw, Leslie M and Roberson, Erik D and Murchison, Charles F and Henson, Rachel L and Benzinger, Tammie L S and others},
title = {{Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals}},
journal = {Nature communications},
year = {2024},
doi = {10.1038/s41467-024-49859-w},
pmid = {38956096},
url = {https://doi.org/10.1038/s41467-024-49859-w}
}
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