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Microbiome: A Key Regulator of Body-Brain Interactions
Kenneth J O'Riordan, Maria R Aburto, Jatin Nagpal, Gerard Clarke, John F Cryan. Advances in experimental medicine and biology, 2025
Topic: Gut, metabolism and diet
The gut microbiota, consisting of trillions of microorganisms, plays a critical role in regulating host physiology, including metabolism, immune responses, and brain function. This chapter examines the microbiota-gut-brain axis, a multifaceted bidirectional communication system connecting gut microbial activity with central nervous system processes through immune pathways, metabolic byproducts, and neural circuits like the vagus nerve. The evolution of the gut microbiota throughout an individual's life-from early developmental influences like birth mode and antibiotic use to changes associated with aging and neurodegenerative conditions-highlights its dynamic nature. The chapter reviews experimental approaches and microbiome-based interventions to demonstrate the influence of gut microbiota on neurological conditions such as autism spectrum disorder, anxiety, and Alzheimer's disease. Finally, it emphasises the importance of advancing microbiome-targeted therapies, integrating emerging technologies, and clinical trials to develop personalised strategies for enhancing brain health through gut microbiome modulation.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
O'Riordan, K. J., Aburto, M. R., Nagpal, J., Clarke, G., & Cryan, J. F. (2025). Microbiome: A Key Regulator of Body-Brain Interactions. Advances in experimental medicine and biology. https://doi.org/10.1007/978-3-031-89525-8_6
Vancouver
O'Riordan KJ, Aburto MR, Nagpal J, Clarke G, Cryan JF. Microbiome: A Key Regulator of Body-Brain Interactions. Advances in experimental medicine and biology. 2025. doi:10.1007/978-3-031-89525-8_6. PMID: 40442386.
BibTeX
@article{oriordan2025-40442386,
author = {O'Riordan, Kenneth J and Aburto, Maria R and Nagpal, Jatin and Clarke, Gerard and Cryan, John F},
title = {{Microbiome: A Key Regulator of Body-Brain Interactions}},
journal = {Advances in experimental medicine and biology},
year = {2025},
doi = {10.1007/978-3-031-89525-8_6},
pmid = {40442386},
url = {https://doi.org/10.1007/978-3-031-89525-8_6}
}
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Key findings
- The evolution of the gut microbiota throughout an individual's life-from early developmental influences like birth mode and antibiotic use to changes associated with aging and neurodegenerative conditions-highlights its dynamic nature.
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Advances in experimental medicine and biology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40442386) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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