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52/100

✓ Peer-reviewed alzhub usefulness score 52 out of 100. Inflammation and the immune system

Topic: Brain proteins, microglia and lab models

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects in neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, and anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Dementia, Multiple Sclerosis (MS), Stroke, and Huntington's Disease (HD). Polyphenols have been extensively studied for their ability to regulate inflammatory responses by modulating the activity of pro-inflammatory genes and influencing signal transduction pathways, thereby reducing neuroinflammation and neuronal death. Additionally, polyphenols have shown promise in modulating various cellular signaling pathways associated with neuronal viability, synaptic plasticity, and cognitive function. Epidemiological and clinical studies highlight the potential of polyphenol-rich diets to decrease the risk and alleviate symptoms of neurodegenerative disorders and neuroinflammation. Furthermore, polyphenols have demonstrated their therapeutic potential through the regulation of key signaling pathways such as Akt, Nrf2, STAT, and MAPK, which play critical roles in neuroprotection and the body's immune response. This review emphasizes the growing body of evidence supporting the therapeutic potential of polyphenols in combating neurodegeneration and neuroinflammation, as well as enhancing brain health. Despite the substantial evidence and promising hypotheses, further research and clinical investigations are necessary to fully understand the role of polyphenols and establish them as advanced therapeutic targets for age-related neurodegenerative diseases and neuroinflammatory conditions.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Jalouli, M., Rahman, M. A., Biswas, P., Rahman, H., Harrath, A. H., Lee, I.-S., et al. (2025). Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2025.1492517

Vancouver

Jalouli M, Rahman MA, Biswas P, Rahman H, Harrath AH, Lee I.-S, et al. Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review. Frontiers in Pharmacology. 2025. doi:10.3389/fphar.2025.1492517. PMID: 39981183.

BibTeX

@article{jalouli2025-39981183,
  author  = {Jalouli, Maroua and Rahman, Md. Ataur and Biswas, Partha and Rahman, Hasanur and Harrath, Abdel Halim and Lee, In-Seon and Kang, Sojin and Choi, Jinwon and others},
  title   = {{Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review}},
  journal = {Frontiers in Pharmacology},
  year    = {2025},
  doi     = {10.3389/fphar.2025.1492517},
  pmid    = {39981183},
  url     = {https://doi.org/10.3389/fphar.2025.1492517}
}

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Key findings

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects in neurological diseases and neuroinflammation.
Additionally, polyphenols have shown promise in modulating various cellular signaling pathways associated with neuronal viability, synaptic plasticity, and cognitive function.
Furthermore, polyphenols have demonstrated their therapeutic potential through the regulation of key signaling pathways such as Akt, Nrf2, STAT, and MAPK, which play critical roles in neuroprotection and the body's immune response.

Why it matters

This review summarizes evidence that polyphenols from plant foods have antioxidant, anti-inflammatory, and anti-amyloid properties that may help in Alzheimer's and other brain diseases. It reports potential from epidemiological and clinical studies but does not establish that polyphenols prevent or treat Alzheimer's disease.

Study details

Evidence strengthLow

How this study scored 52/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Frontiers in Pharmacology)
Journal's citation record	2 / 4	Frontiers in Pharmacology: journal h-index 242 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 127 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	42.3 citations a year over 3 year(s) since 2025
Impact for its field and year	6 / 6	Cited 50.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	3 / 4	Cited 127 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Bonglee Kim: h-index 48 (OpenAlex, whole career)
Institution's track record	1 / 3	Wayne State University: institution h-index 864 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 7 institution(s) in 4 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39981183)
Free to read	2 / 2	Free to read
Total	52 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

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