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Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair
De Ponti FF, Bujko A, Liu Z, Collins PJ, Schuermans S, Maueroder C, Amstelveen S, Thoné T et al.. Immunity, 2025-01-24
Topic: Brain proteins, microglia and lab models
Our understanding of the functional heterogeneity of resident versus recruited macrophages in the diseased liver is limited. A population of recruited lipid-associated macrophages (LAMs) has been reported to populate the diseased liver alongside resident Kupffer cells (KCs). However, the precise roles of these distinct macrophage subsets remain elusive.
Key findings
- A population of recruited lipid-associated macrophages (LAMs) has been reported to populate the diseased liver alongside resident Kupffer cells (KCs).
- However, the precise roles of these distinct macrophage subsets remain elusive.
- Here, using proteogenomics, we have identified LAMs in multiple models of liver injury.
- Moreover, we found that this phenotype is not specific to recruited macrophages, as a subset of resident KCs can also adopt a LAM-like phenotype in the mouse and human liver.
Why it matters
This study identified lipid-associated macrophages in models of liver injury and found some resident Kupffer cells can adopt a similar phenotype. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 51/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Immunity) |
| Journal's citation record | 4 / 4 | Immunity: journal h-index 567 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 89 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 29.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 6 / 6 | Cited 44.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 89 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Charlotte L. Scott: h-index 45 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | KU Leuven: institution h-index 1,386 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 12 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39862865) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
De Ponti, F. F., Bujko, A., Liu, Z., Collins, P. J., Schuermans, S., Maueroder, C., et al. (2025). Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair. Immunity. https://doi.org/10.1016/j.immuni.2025.01.002
Vancouver
De Ponti FF, Bujko A, Liu Z, Collins PJ, Schuermans S, Maueroder C, et al. Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair. Immunity. 2025. doi:10.1016/j.immuni.2025.01.002. PMID: 39862865.
BibTeX
@article{deponti2025-39862865,
author = {De Ponti, F. F. and Bujko, A. and Liu, Z. and Collins, P. J. and Schuermans, S. and Maueroder, C. and Amstelveen, S. and Thoné, T. and others},
title = {{Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair}},
journal = {Immunity},
year = {2025},
doi = {10.1016/j.immuni.2025.01.002},
pmid = {39862865},
url = {https://doi.org/10.1016/j.immuni.2025.01.002}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 21.