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State-dependent functional network connectivity alterations in post-stroke dementia with subcortical lesions
Huaying Cai, Nan Zhang, Yun Jiang, Qianwen Wu, Linhui Ni, Guocan Han, Jiaao Liaocheng, Dan Wu et al.. Journal of Alzheimer s Disease, 2025-02-01
Topic: Brain proteins, microglia and lab models
We identified 13 meaningful resting-state networks, and the dFNC among them derived four states exhibiting different connection patterns. In state III with strong connections within high-order networks, PSD and PSND both showed increased connectivity between visual network (VN) and high-order networks relative to NC; in state I with weak connections among all networks, PSD showed weaker connectivity between default mode network (DMN) and executive control network and between VN and DMN compared to PSND. Moreover, the dFNC measures showed significant correlations with cognitive assessments of patients. Our findings suggest that PSD-specific functional network connectivity (FNC) alterations are state-dependent, and dFNC reveals a coexistence mechanism of functional impairment and compensation in large-scale brain networks, which is not observed in static FNC. This offers a new perspective to understand the neural mechanisms of PSD.
Key findings
- We identified 13 meaningful resting-state networks, and the dFNC among them derived four states exhibiting different connection patterns.
- In state III with strong connections within high-order networks, PSD and PSND both showed increased connectivity between visual network (VN) and high-order networks relative to NC; in state I with weak connections among all networks, PSD showed weaker connectivity between default mode network (DMN) and executive control network and between VN and DMN compared to PSND.
- Moreover, the dFNC measures showed significant correlations with cognitive assessments of patients.
- Our findings suggest that PSD-specific functional network connectivity (FNC) alterations are state-dependent, and dFNC reveals a coexistence mechanism of functional impairment and compensation in large-scale brain networks, which is not observed in static FNC.
- This offers a new perspective to understand the neural mechanisms of PSD.
Why it matters
This study found that functional network connectivity alterations in post-stroke dementia with subcortical lesions are state-dependent, showing both impairment and compensation in large-scale brain networks. It offers a perspective on the neural mechanisms of post-stroke dementia but does not test any treatment or prevention.
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Study details
- Participants19
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer s Disease) |
| Journal's citation record | 2 / 4 | Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 19 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Zhiyong Zhao: h-index 26 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Oxford: institution h-index 2,205 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40012224) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Cai, H., Zhang, N., Jiang, Y., Wu, Q., Ni, L., Han, G., et al. (2025). State-dependent functional network connectivity alterations in post-stroke dementia with subcortical lesions. Journal of Alzheimer s Disease. https://doi.org/10.1177/13872877241313056
Vancouver
Cai H, Zhang N, Jiang Y, Wu Q, Ni L, Han G, et al. State-dependent functional network connectivity alterations in post-stroke dementia with subcortical lesions. Journal of Alzheimer s Disease. 2025. doi:10.1177/13872877241313056. PMID: 40012224.
BibTeX
@article{cai2025-40012224,
author = {Cai, Huaying and Zhang, Nan and Jiang, Yun and Wu, Qianwen and Ni, Linhui and Han, Guocan and Liaocheng, Jiaao and Wu, Dan and others},
title = {{State-dependent functional network connectivity alterations in post-stroke dementia with subcortical lesions}},
journal = {Journal of Alzheimer s Disease},
year = {2025},
doi = {10.1177/13872877241313056},
pmid = {40012224},
url = {https://doi.org/10.1177/13872877241313056}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.