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Parallel changes in cognition, neuropsychiatric symptoms, and amyloid in cognitively unimpaired older adults and those with mild cognitive impairment
Alyssa N. De Vito, Zachary J. Kunicki, Hannah E. Joyce, Edward D. Huey, Richard Norman Jones, for the Alzheimer's Disease Neuroimaging Initiative. Alzheimer s & Dementia, 2025-02-01
Topic: Risk, prevention and care in population studies
NPS was longitudinally associated with performance in each cognitive domain. Negative baseline Aβ-cognition associations were observed in three cognitive domains. No Aβ-NPS associations were observed. This study demonstrated strong longitudinal relationships between NPS and cognition in preclinical and prodromal stages of AD. Future studies should incorporate NPS into models of disease trajectories to improve early detection and prediction of disease progression. HIGHLIGHTS: Co-occurring changes in Aβ, cognition, and neuropsychiatric symptoms are understudied. We found relationships between neuropsychiatric symptoms and cognition. We found baseline, but not longitudinal, Aβ and cognition associations. Changes in neuropsychiatric symptoms should be included in early detection models of ADRD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
De Vito, A. N., Kunicki, Z. J., Joyce, H. E., Huey, E. D., Jones, R. N., & Alzheimer's Disease Neuroimaging Initiative. (2025). Parallel changes in cognition, neuropsychiatric symptoms, and amyloid in cognitively unimpaired older adults and those with mild cognitive impairment. Alzheimer s & Dementia. https://doi.org/10.1002/alz.14568
Vancouver
De Vito AN, Kunicki ZJ, Joyce HE, Huey ED, Jones RN, Alzheimer's Disease Neuroimaging Initiative. Parallel changes in cognition, neuropsychiatric symptoms, and amyloid in cognitively unimpaired older adults and those with mild cognitive impairment. Alzheimer s & Dementia. 2025. doi:10.1002/alz.14568. PMID: 39936256.
BibTeX
@article{devito2025-39936256,
author = {De Vito, Alyssa N. and Kunicki, Zachary J. and Joyce, Hannah E. and Huey, Edward D. and Jones, Richard Norman and {Alzheimer's Disease Neuroimaging Initiative}},
title = {{Parallel changes in cognition, neuropsychiatric symptoms, and amyloid in cognitively unimpaired older adults and those with mild cognitive impairment}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.14568},
pmid = {39936256},
url = {https://doi.org/10.1002/alz.14568}
}
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Key findings
- NPS was longitudinally associated with performance in each cognitive domain.
- Negative baseline Aβ-cognition associations were observed in three cognitive domains.
- This study demonstrated strong longitudinal relationships between NPS and cognition in preclinical and prodromal stages of AD.
- Future studies should incorporate NPS into models of disease trajectories to improve early detection and prediction of disease progression.
- HIGHLIGHTS: Co-occurring changes in Aβ, cognition, and neuropsychiatric symptoms are understudied.
Why it matters
Neuropsychiatric symptoms were longitudinally associated with performance in each cognitive domain, while amyloid was associated with cognition only at baseline and not with neuropsychiatric symptoms. This supports including neuropsychiatric symptom changes in early detection models, but it does not test any treatment, cure or prevention.
Study details
- Study designlongitudinal study
- Participants1,247
- Evidence strengthModerate
How this study scored 55/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 53 of the 96 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,247 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 11 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 7.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 1 / 3 | Brown University: institution h-index 1,120 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39936256) |
| Free to read | 2 / 2 | Free to read |
| Points | 53 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 53 of the 96 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
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