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Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates
Matthew A Rouse, Masud Husain, Peter Garrard, Karalyn E. Patterson, James Benedict Rowe, Matthew A. Lambon Ralph. Brain, 2025-02-10
Topic: Risk, prevention and care in population studies
We found a wide range of behavioural changes across FTD. Comparisons of self and informant ratings revealed strong discrepancies in the perspective of the caregiver versus the patient. Logistic regression revealed that neuropsychological measures had better discriminative accuracy for bvFTD versus SD than caregiver-reported behavioural measures. More severe apathy in both FTD subtypes was associated with: (i) increased levels of impaired executive function; and (ii) anterior cingulate cortex atrophy. Together, these findings highlight the presence of a wide range of behavioural changes in both bvFTD and SD, which vary by degree rather than quality.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Rouse, M. A., Husain, M., Garrard, P., Patterson, K. E., Rowe, J. B., & Ralph, M. A. L. (2025). Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates. Brain. https://doi.org/10.1093/brain/awaf061
Vancouver
Rouse MA, Husain M, Garrard P, Patterson KE, Rowe JB, Ralph MAL. Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates. Brain. 2025. doi:10.1093/brain/awaf061. PMID: 39938002.
BibTeX
@article{rouse2025-39938002,
author = {Rouse, Matthew A and Husain, Masud and Garrard, Peter and Patterson, Karalyn E. and Rowe, James Benedict and Ralph, Matthew A. Lambon},
title = {{Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates}},
journal = {Brain},
year = {2025},
doi = {10.1093/brain/awaf061},
pmid = {39938002},
url = {https://doi.org/10.1093/brain/awaf061}
}
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Key findings
- We found a wide range of behavioural changes across FTD.
- Comparisons of self and informant ratings revealed strong discrepancies in the perspective of the caregiver versus the patient.
- Logistic regression revealed that neuropsychological measures had better discriminative accuracy for bvFTD versus SD than caregiver-reported behavioural measures.
- More severe apathy in both FTD subtypes was associated with: (i) increased levels of impaired executive function; and (ii) anterior cingulate cortex atrophy.
- Together, these findings highlight the presence of a wide range of behavioural changes in both bvFTD and SD, which vary by degree rather than quality.
Why it matters
This study found a wide range of behavioural changes in both behavioural variant and semantic dementia, with more severe apathy linked to impaired executive function and anterior cingulate cortex atrophy. It concerns characterising symptoms and their correlates, not treating or curing dementia.
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Study details
- Evidence strengthLow
How this study scored 50/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 14 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 4 / 6 | Cited 8.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Matthew A. Lambon Ralph: h-index 105 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Oxford: institution h-index 2,205 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39938002) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
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