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Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease
Anna Mengr, Zuzana Šmotková, Andrea Pačesová, Blanka Železná, Jaroslav Kuneš, Lenka Maletı́nská. Journal of Neuroimmune Pharmacology, 2025-02-11
Topic: Brain proteins, microglia and lab models
It primarily affects cerebral regions responsible for cognition, memory, and language processing, significantly impeding the functional independence of patients.
Key findings
- It primarily affects cerebral regions responsible for cognition, memory, and language processing, significantly impeding the functional independence of patients.
Why it matters
The available text only describes that Alzheimer's disease affects brain regions for cognition, memory, and language and impairs independence. It provides no findings on treating, curing, or preventing the disease.
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Neuroimmune Pharmacology) |
| Journal's citation record | 1 / 4 | Journal of Neuroimmune Pharmacology: journal h-index 108 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “transgenic”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 6 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 3.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Lenka Maletı́nská: h-index 29 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Charles University: institution h-index 721 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39932627) |
| Free to read | 2 / 2 | Free to read |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1007/s11481-025-10174-w
- PubMed: 39932627
- Original source →
- Free full text: Journal of Neuroimmune Pharmacology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Mengr, A., Šmotková, Z., Pačesová, A., Železná, B., Kuneš, J., & Maletı́nská, L. (2025). Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease. Journal of Neuroimmune Pharmacology. https://doi.org/10.1007/s11481-025-10174-w
Vancouver
Mengr A, Šmotková Z, Pačesová A, Železná B, Kuneš J, Maletı́nská L. Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease. Journal of Neuroimmune Pharmacology. 2025. doi:10.1007/s11481-025-10174-w. PMID: 39932627.
BibTeX
@article{mengr2025-39932627,
author = {Mengr, Anna and Šmotková, Zuzana and Pačesová, Andrea and Železná, Blanka and Kuneš, Jaroslav and Maletı́nská, Lenka},
title = {{Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease}},
journal = {Journal of Neuroimmune Pharmacology},
year = {2025},
doi = {10.1007/s11481-025-10174-w},
pmid = {39932627},
url = {https://doi.org/10.1007/s11481-025-10174-w}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
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Also tagged “mice”
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