Newest studies

Differential miRNA expression in neural-enriched extracellular vesicles as potential biomarker for frontotemporal dementia and bipolar disorder

46/100 ✓ Peer-reviewed Lewy body dementia Neurobiology of Disease

Key finding: Among 754 miRNAs, 11 were significantly deregulated in bvFTD and BD. +3 more findings

• Other Dementias
• Biomarkers

Full summary, score breakdown and related studies → Original source

Diabetes status, duration, and risk of dementia among ischemic stroke patients

52/100 ✓ Peer-reviewed Risk factors Alzheimer s Research & Therapy

Key finding: Among 118,790 participants (average age 64.26 ± 9.95 years, 48% male), 16.7% developed dementia during an average follow-up of 7.3 ± 2.3 years. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Online Communities as a Support System for Alzheimer Disease and Dementia Care: Large-Scale Exploratory Study

37/100 ✓ Peer-reviewed Caregiving JMIR Aging

Key finding: Our analysis revealed a diverse range of topics reflecting community members' varying needs and concerns of individuals affected by AD/ADRD. +4 more findings

• Caregiving
• Digital Tools

Full summary, score breakdown and related studies → Original source

Gut Microbiota Modulation Through Mediterranean Diet Foods: Implications for Human Health

49/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: Clinical and preclinical studies have proved that the MD is associated with increased microbial diversity, reduced pro-inflammatory bacteria, and improved markers of insulin sensitivity, lipid metabolism, and cognitive function. +2 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Chiral Bimetallic Pt@Au Octapods with Spiral Four-Petal Flower-Like Symmetric Configuration as Sensitive SERS Probes

43/100 ✓ Peer-reviewed Biomarkers Angewandte Chemie (International ed. in English)

Key finding: The different association constants arose from the unique chiral recognition capabilities of the CT ligands on the surfaces of the l-Pt@Au octapods, which allowed them to form specific hydrogen bonds with Aβ40 and Aβ42 monomers and fibrils, producing significant differences in their Raman spectra. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Markers of Left Atrial Myopathy: Prognostic Usefulness for Ischemic Stroke and Dementia in People in Sinus Rhythm

60/100 ✓ Peer-reviewed Vascular contributions Stroke

Key finding: Among 4712 participants (59% female; mean age, 74 years), 193 ischemic strokes and 769 dementia cases were ascertained over a median follow-up of 8.3 years. +4 more findings

Full summary, score breakdown and related studies → Original source

Elevated TDP-43 serum levels associated with postoperative delirium following major cardiac surgery

47/100 ✓ Peer-reviewed Brain tissue and pathology Brain Behavior & Immunity - Health

Key finding: Total serum TDP-43 levels increased by 16.5% (95% CI: 5.9%-27.9%, p = 0.0021) on postoperative day one compared to baseline levels. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Screening tools for subjective cognitive decline and mild cognitive impairment based on task-state prefrontal functional connectivity: a functional near-infrared spectroscopy study

45/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage

Key finding: Statistical analysis revealed a trend toward more impaired prefrontal FC with declining cognitive function. +4 more findings

• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China

57/100 ✓ Peer-reviewed How common it is General Psychiatry

Key finding: Among our participants, aMCI and VCIND demonstrated prevalence of 14.83% and 2.71%, respectively, and annual incidence (per 1000 person-years) of 69.6 and 10.6, respectively. +4 more findings

• Risk Factors
• Prevention
• Early Stage

Full summary, score breakdown and related studies → Original source

The disease burden, risk factors and future predictions of Alzheimer's disease and other types of dementia in Asia from 1990 to 2021

46/100 ✓ Peer-reviewed How common it is The Journal of Prevention of Alzheimer s Disease

Key finding: According to the analysis of the GBD database in 2021, the deaths, DALYs, incidence, and prevalence of ADOD increased by 297.34 %, 249.54 %, 244.73 %, and 250.44 % in Asia from 1990 to 2021. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Music-based therapeutic interventions for people with dementia (Cochrane review update)

73/100 ✓ Peer-reviewed Caregiving Cochrane Database of Systematic Reviews

Key finding: For music-based therapeutic interventions compared to usual care, we found moderate-certainty evidence that, at the end of treatment, music-based therapeutic interventions probably improved depressive symptoms slightly (standardised mean difference (SMD) -0.23, 95% confidence interval (CI) -0.42 to -0.04; 9 studies, 441 participants), and we found low-certainty evidence that it may have improved overall behavioural problems (SMD -0.31, 95% CI -0.60 to -0.02; 10 studies, 385 participants). +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Healthy dietary patterns in relation to cognitive performance and Alzheimer's disease mortality

55/100 ✓ Peer-reviewed Prevention and risk The journal of prevention of Alzheimer's disease

Key finding: A total of 260 AD deaths occurred during a median follow-up of 9.8 years. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

TREM2 risk variants and associated endophenotypes in alzheimer's disease

59/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's research & therapy

Key finding: TREM2 variant carriers (64 ± 7 years, 54% female) did not show distinct clinical measures of AD at presentation compared to AD patients not carrying a TREM2 variant (64 ± 7 years, 52% female). +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Safety and effectiveness of the anti-amyloid monoclonal antibody (mAb) drug lecanemab for early Alzheimer's disease: The pharmacovigilance perspective

45/100 ✓ Peer-reviewed Treatments British journal of clinical pharmacology

Key finding: Subsequently, the EMA recommended the marketing approval of lecanemab in November 2024 following a re-examination of further data submitted by the Marketing Authorisation Holder. +4 more findings

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Neuroinflammatory fluid biomarkers in patients with Alzheimer's disease: a systematic literature review

72/100 ✓ Peer-reviewed Inflammation and the immune system Molecular psychiatry

Key finding: Neuroinflammatory biomarkers are associated with AD progression. +4 more findings

• Biomarkers
• Brain Biology
• Early Stage

Full summary, score breakdown and related studies → Original source

Effect of Incident Stroke on Dementia Risk Over 10 Years in a Cohort of Asian American and Non-Latino White Older Adults in California

61/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: We included 147,986 participants (Chinese [n = 6,034], Filipino [n = 4,649], Japanese [n = 3,099], South Asian [n = 996], non-Latino White [n = 133,208]); the mean baseline age ranged from 69 to 72 years, and the percentage of female participants ranged from 40% to 63% across groups. +4 more findings

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

Healthy dietary intake diminishes the effect of cerebral small vessel disease on cognitive performance in older adults

35/100 ✓ Peer-reviewed Vascular contributions Frontiers in Neurology

Key finding: Dietary intake moderated the association between several cSVD biomarkers and MoCA scores such that the expected negative association between cSVD biomarkers and cognition was seen at low levels of healthy dietary intake, but not at medium or high levels. +2 more findings

• Other Dementias
• Lifestyle

Full summary, score breakdown and related studies → Original source

Models to Identify Small Brain White Matter Hyperintensity Lesions

37/100 ✓ Peer-reviewed Vascular contributions Applied Sciences

Key finding: In this context, detecting and classifying brain lesions constitute a critical area of research in medical image processing, significantly impacting clinical practice. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Data‐driven discovery of midlife cardiometabolic profile associated with incident early‐onset and late‐onset dementia

41/100 ✓ Peer-reviewed Brain tissue and pathology Diabetes Obesity and Metabolism

Key finding: During a median follow-up of 14.1 years, 279 early-onset dementia cases and 3167 late-onset dementia cases were documented. +4 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Sex Differences in Risk Factors for Incident Sepsis Hospitalizations: A Prospective Cohort Study Using the UK Biobank

52/100 ✓ Peer-reviewed Long-term cohort studies The Journal of Infectious Diseases

Key finding: Of 490 783 participants, 21 468 (47.6% women) experienced an incident sepsis hospitalization. +4 more findings

• Risk Factors
• Care Services

Full summary, score breakdown and related studies → Original source

Use of artificial intelligence in neurological disorders diagnosis: A scientometric study

34/100 ✓ Peer-reviewed Digital health tools World Journal of Methodology

Key finding: Research on AI's role in diagnosing neurological disorders is becoming widely recognized for its growing importance. +1 more finding

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Cornea Oculomics: A Clinical Blueprint for Extending Corneal Diagnostics and Artificial Intelligence in Systemic Health Insights

39/100 ✓ Peer-reviewed Digital health tools Diagnostics

Key finding: Despite its growing recognition, gaps remain in the literature regarding the clinical applications of oculomics. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Wealth Disparities in End-of-Life Symptom Burden Among Older Adults

54/100 ✓ Peer-reviewed Disparities JAMA Network Open

Key finding: Of 8976 decedents (mean [SD] age, 81.3 [8.6] years; 4927 women [55.1%] women) in the cohort, 2197 (22.5%) were included in the low wealth category, 4534 (50.5%) in the medium wealth category, and 2245 (27.1%) in the high wealth category. +4 more findings

• Health Equity
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Effectiveness of exercise for improving cognition, memory and executive function: a systematic umbrella review and meta-meta-analysis

76/100 ✓ Peer-reviewed Prevention and risk British Journal of Sports Medicine

Key finding: 133 systematic reviews (2,724 RCTs and 258 279 participants) were included. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease

65/100 ✓ Peer-reviewed Laboratory science Nature Medicine

Key finding: We compare actively immunized patients with AD with nonimmunized patients with AD and neurologically healthy controls, identifying distinct microglial states associated with Aβ clearance. +1 more finding

• Brain Biology
• Treatments
• Genetics

Full summary, score breakdown and related studies → Original source