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Circulating metabolomic profile of the MIND diet and its relation to cognition in middle‐aged and older adults
Hui Chen, Jie Shen, Yang Tao, Yaodan Zhang, Mengyan Gao, Yuan Ma, Yan Zheng, Geng Zong et al.. iMetaOmics., 2025-02-10
Topic: Risk, prevention and care in population studies
The Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) diet has been related to a lower risk of dementia and better cognitive function. This study identified 47 circulating metabolites associated with the alternate MIND diet score (aMIND) in the UK Biobank (45,906 participants, 168 metabolites measured) and Whitehall II (6193 participants, 152 metabolites measured). Unsaturated fatty acids showed the strongest positive associations with the aMIND, and very low-density lipoprotein measures and glycoprotein acetyls showed the strongest inverse associations. We constructed a metabolomic signature score (MIND-MetS) to objectively reflect MIND diet adherence. Both aMIND and MIND-MetS were associated with better cognitive outcomes in participants aged 55 years or older, and the MIND-MetS partially mediated the aMIND-cognition associations. In summary, the rapid and widely accessible nuclear magnetic resonance-based metabolomic measure could objectively reflect MIND diet adherence. Moreover, our findings offered insights into the intricate connections among diet, metabolism, and cognition.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Chen, H., Shen, J., Tao, Y., Zhang, Y., Gao, M., Ma, Y., et al. (2025). Circulating metabolomic profile of the MIND diet and its relation to cognition in middle‐aged and older adults. iMetaOmics.. https://doi.org/10.1002/imo2.61
Vancouver
Chen H, Shen J, Tao Y, Zhang Y, Gao M, Ma Y, et al. Circulating metabolomic profile of the MIND diet and its relation to cognition in middle‐aged and older adults. iMetaOmics.. 2025. doi:10.1002/imo2.61. PMID: 41675703.
BibTeX
@article{chen2025-41675703,
author = {Chen, Hui and Shen, Jie and Tao, Yang and Zhang, Yaodan and Gao, Mengyan and Ma, Yuan and Zheng, Yan and Zong, Geng and others},
title = {{Circulating metabolomic profile of the MIND diet and its relation to cognition in middle‐aged and older adults}},
journal = {iMetaOmics.},
year = {2025},
doi = {10.1002/imo2.61},
pmid = {41675703},
url = {https://doi.org/10.1002/imo2.61}
}
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Key findings
- The Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) diet has been related to a lower risk of dementia and better cognitive function.
- This study identified 47 circulating metabolites associated with the alternate MIND diet score (aMIND) in the UK Biobank (45,906 participants, 168 metabolites measured) and Whitehall II (6193 participants, 152 metabolites measured).
- Both aMIND and MIND-MetS were associated with better cognitive outcomes in participants aged 55 years or older, and the MIND-MetS partially mediated the aMIND-cognition associations.
- Moreover, our findings offered insights into the intricate connections among diet, metabolism, and cognition.
Why it matters
This study found that a blood marker reflecting adherence to the MIND diet was linked to better cognitive outcomes in people aged 55 and older. It is an observational study, so it cannot prove that the diet or the marker causes better cognition or prevents dementia.
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Study details
- Participants45,906
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (iMetaOmics.) |
| Journal's citation record | 0 / 4 | IMetaOmics.: journal h-index 16 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 4 / 4 | 45,906 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 8 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 6.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Changzheng Yuan: h-index 41 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 9 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41675703) |
| Free to read | 2 / 2 | Free to read |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
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