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51/100

✓ Peer-reviewed alzhub usefulness score 51 out of 100. How common it is

Topic: Risk, prevention and care in population studies

There was a significant difference in dementia incidence in the HSV-infected group versus the control. Individuals with a history of HSV, HSV1, HSV2, and coinfection all showed a significant risk of developing dementia compared to controls. Males with HSV2 are at a higher risk of dementia outcome than females with HSV2. While consistent with previous reports, these findings are the first to establish a higher risk of developing dementia in patients who have any HSV diagnosis using a nationwide, population-based matched cohort study in the United States.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Araya, K., Watson, R., Khanipov, K., Golovko, G., & Taglialatela, G. (2025). Increased risk of dementia associated with herpes simplex virus infections: Evidence from a retrospective cohort study using U.S. electronic health records. Journal of Alzheimer s Disease. https://doi.org/10.1177/13872877251317228

Vancouver

Araya K, Watson R, Khanipov K, Golovko G, Taglialatela G. Increased risk of dementia associated with herpes simplex virus infections: Evidence from a retrospective cohort study using U.S. electronic health records. Journal of Alzheimer s Disease. 2025. doi:10.1177/13872877251317228. PMID: 39956964.

BibTeX

@article{araya2025-39956964,
  author  = {Araya, Kunio and Watson, Riley and Khanipov, Kamil and Golovko, George and Taglialatela, Giulio},
  title   = {{Increased risk of dementia associated with herpes simplex virus infections: Evidence from a retrospective cohort study using U.S. electronic health records}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251317228},
  pmid    = {39956964},
  url     = {https://doi.org/10.1177/13872877251317228}
}

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Key findings

There was a significant difference in dementia incidence in the HSV-infected group versus the control.
Individuals with a history of HSV, HSV1, HSV2, and coinfection all showed a significant risk of developing dementia compared to controls.
Males with HSV2 are at a higher risk of dementia outcome than females with HSV2.
While consistent with previous reports, these findings are the first to establish a higher risk of developing dementia in patients who have any HSV diagnosis using a nationwide, population-based matched cohort study in the United States.

Why it matters

This retrospective cohort using U.S. electronic health records found that people with a history of herpes simplex virus, HSV1, HSV2, or coinfection had a significantly higher risk of developing dementia than controls. It reports an association only and does not test whether treating or preventing HSV infection affects dementia risk.

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Study details

Study designcohort study
Evidence strengthModerate

How this study scored 51/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Alzheimer s Disease)
Journal's citation record	2 / 4	Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	3 / 7	Cited 22 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	7.3 citations a year over 3 year(s) since 2025
Impact for its field and year	4 / 6	Cited 13.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	2 / 4	Cited 22 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Giulio Taglialatela: h-index 45 (OpenAlex, whole career)
Institution's track record	0 / 3	The University of Texas Medical Branch at Galveston: institution h-index 655 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39956964)
Free to read	2 / 2	Free to read
Total	51 / 100	—

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