Diversity in United States Dementia Prevention Trials: An Updated Systematic Review of Eligibility Criteria and Recruitment Strategies

Topic: Risk, prevention and care in population studies

Introduction: Given the elevated dementia risk in underrepresented demographic groups in the USA - particularly in Latino and Non-Latino Black individuals compared to Non-Latino White individuals - it is vital that these groups are well-represented in dementia prevention research. Eligibility criteria and recruitment strategies may play a key role in promoting participant diversity. The aim of this review was to examine eligibility criteria and recruitment strategies in US dementia prevention trials in light of participant diversity. A systematic review was conducted using Medline (including PubMed), Embase, Cochrane Library, and CINAHL. We explored the percent White participants for trials using versus not using a specific eligibility criterion or recruitment strategy using Hodges-Lehmann median difference estimation. Of forty-four studies meeting the inclusion criteria, twenty-seven reported on racial/ethnic diversity. Analyses demonstrated that criteria regarding cardiovascular disease, pulmonary disease, hearing impairment, and sedentary lifestyle were associated with relatively high participant diversity, while gastro-intestinal/liver disease, motivation to participate, and language proficiency criteria were associated with relatively little diversity. Information on recruitment strategies was often lacking. Three studies described recruitment efforts explicitly aimed at increasing diversity. Recruitment strategies associated with relatively high racial/ethnic diversity included recruitment via referral/word-of-mouth, television/radio advertising, and recruitment at church. Eligibility criteria could be improved by revisiting and revising how they are defined (e.g., motivation to participate). Regarding recruitment, several recommendations are provided, including (1) lifting barriers to study participation (e.g., through reimbursement), (2) collaborating with community partners, and (3) formally studying the effectiveness of recruitment strategies. .

Key findings

• Introduction: Given the elevated dementia risk in underrepresented demographic groups in the USA - particularly in Latino and Non-Latino Black individuals compared to Non-Latino White individuals - it is vital that these groups are well-represented in dementia prevention research.
• We explored the percent White participants for trials using versus not using a specific eligibility criterion or recruitment strategy using Hodges-Lehmann median difference estimation.
• Analyses demonstrated that criteria regarding cardiovascular disease, pulmonary disease, hearing impairment, and sedentary lifestyle were associated with relatively high participant diversity, while gastro-intestinal/liver disease, motivation to participate, and language proficiency criteria were associated with relatively little diversity.
• Recruitment strategies associated with relatively high racial/ethnic diversity included recruitment via referral/word-of-mouth, television/radio advertising, and recruitment at church.

Why it matters

This review examined eligibility criteria and recruitment strategies in U.S. dementia prevention trials in relation to participant diversity. It does not test any treatment, cure, or prevention for Alzheimer's disease.

Study details

• Study designsystematic review
• Evidence strengthHigh

Read the original

• DOI: 10.1159/000543905
• PubMed: 39947158
• Original source →
• Free full text: Dementia and Geriatric Cognitive Disorders →

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

@article{najoua2025-39947158,
  author  = {Najoua, Lazaar and Van Beek Sabine, E. and Rirash Awaale, F. and Papma Janne, M. and Jaime, Perales-Puchalt and Shaw Ashley, R. and Vidoni Eric, D. and Sanne, Franzen},
  title   = {{Diversity in United States Dementia Prevention Trials: An Updated Systematic Review of Eligibility Criteria and Recruitment Strategies}},
  journal = {Dementia and geriatric cognitive disorders},
  year    = {2025},
  doi     = {10.1159/000543905},
  pmid    = {39947158},
  url     = {https://doi.org/10.1159/000543905}
}

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