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White matter lesions rather than amyloid-β burden are associated with cognitive decline in Alzheimer's disease
Hiroo Kasahara, Masaki Ikeda, Kouki Makioka, Takumi Nakamura, Ryoma Takahashi, Takeshi Kawarabayashi, Etsuko Sanada, Takayuki Suto et al.. Journal of Alzheimer's disease : JAD, 2025-02-16
Topic: Plasma and spinal-fluid biomarkers
We assessed the severity of amyloid-β accumulation and white matter lesions (WML) in the brain, and their association with cognitive decline, in patients (n = 47) with Alzheimer's disease (AD). The mean cortical standardized uptake value ratio (mcSUVR) was derived from amyloid positron emission tomography, while the percentage of WML area relative to brain parenchymal area was determined using magnetic resonance imaging. Cognitive decline was positively correlated with WML severity (r = 0.50, p = 0.042) but not mcSUVR (Aβ accumulation). Managing vascular risk factors can prevent cognitive decline in patients with AD.
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APA 7th
Kasahara, H., Ikeda, M., Makioka, K., Nakamura, T., Takahashi, R., Kawarabayashi, T., et al. (2025). White matter lesions rather than amyloid-β burden are associated with cognitive decline in Alzheimer's disease. Journal of Alzheimer's disease : JAD. https://doi.org/10.1177/13872877251316516
Vancouver
Kasahara H, Ikeda M, Makioka K, Nakamura T, Takahashi R, Kawarabayashi T, et al. White matter lesions rather than amyloid-β burden are associated with cognitive decline in Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2025. doi:10.1177/13872877251316516. PMID: 39956952.
BibTeX
@article{kasahara2025-39956952,
author = {Kasahara, Hiroo and Ikeda, Masaki and Makioka, Kouki and Nakamura, Takumi and Takahashi, Ryoma and Kawarabayashi, Takeshi and Sanada, Etsuko and Suto, Takayuki and others},
title = {{White matter lesions rather than amyloid-β burden are associated with cognitive decline in Alzheimer's disease}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2025},
doi = {10.1177/13872877251316516},
pmid = {39956952},
url = {https://doi.org/10.1177/13872877251316516}
}
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Key findings
- We assessed the severity of amyloid-β accumulation and white matter lesions (WML) in the brain, and their association with cognitive decline, in patients (n = 47) with Alzheimer's disease (AD).
- The mean cortical standardized uptake value ratio (mcSUVR) was derived from amyloid positron emission tomography, while the percentage of WML area relative to brain parenchymal area was determined using magnetic resonance imaging.
- Cognitive decline was positively correlated with WML severity (r = 0.50, p = 0.042) but not mcSUVR (Aβ accumulation).
- Managing vascular risk factors can prevent cognitive decline in patients with AD.
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Study details
- Participants47
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 47 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39956952) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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