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65/100

✓ Peer-reviewed alzhub usefulness score 65 out of 100. Biomarkers

Topic: Amyloid, tau and blood-test diagnosis

Importance Understanding the characteristics of discordance between plasma biomarkers and positron emission tomography (PET) results in Alzheimer disease (AD) is crucial for accurate interpretation of the findings. Objective To compare (1) medical comorbidities affecting plasma biomarker concentrations, (2) imaging and clinical features, and (3) cognitive changes between plasma biomarker and PET discordant and concordant cases. Design, setting, and participants This multicenter cohort study, conducted between 2016 and 2023, included individuals with unimpaired cognition, mild cognitive impairment, or Alzheimer-type dementia, who had both amyloid β (Aβ) PET imaging and plasma biomarkers. A subset of participants also underwent tau PET imaging. Exposures Participants were categorized into 4 groups based on their plasma and PET biomarker results: plasma-/PET-, plasma+/PET-, plasma-/PET+, and plasma+/PET+. Main outcomes and measures Clinical characteristics were compared between the 4 groups, focusing on the discordant groups. Results A total of 2611 participants (mean [SD] age was 71.2 [8.7] years; 1656 female [63.4%]), of whom 124 additionally underwent tau PET, were included. Among the plasma biomarkers, phosphorylated tau (p-tau) 217 exhibited the highest concordance rate with Aβ (2326 of 2571 [90.5%]) and tau (100 of 120 [83.3%]) PET. The p-tau217+/Aβ PET- group was older (mean [SD] age, 75.8 [7.2] years vs 70.0 [8.8] years; P Conclusions and relevance Results of this cohort study suggest that the mechanisms underlying the discordance between plasma biomarkers and PET findings may be multifaceted, underscoring the need to consider the temporal dynamics and biological variability of plasma biomarkers.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Yun, J., Shin, D., Lee, E. H., Kim, J. P., Ham, H., Gu, Y., et al. (2025). Temporal Dynamics and Biological Variability of Alzheimer Biomarkers. JAMA neurology. https://doi.org/10.1001/jamaneurol.2024.5263

Vancouver

Yun J, Shin D, Lee EH, Kim JP, Ham H, Gu Y, et al. Temporal Dynamics and Biological Variability of Alzheimer Biomarkers. JAMA neurology. 2025. doi:10.1001/jamaneurol.2024.5263. PMID: 39960728.

BibTeX

@article{yun2025-39960728,
  author  = {Yun, J. and Shin, D. and Lee, E. H. and Kim, J. P. and Ham, H. and Gu, Y. and Chun, M. Y. and Kang, S. H. and others},
  title   = {{Temporal Dynamics and Biological Variability of Alzheimer Biomarkers}},
  journal = {JAMA neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2024.5263},
  pmid    = {39960728},
  url     = {https://doi.org/10.1001/jamaneurol.2024.5263}
}

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Key findings

Importance Understanding the characteristics of discordance between plasma biomarkers and positron emission tomography (PET) results in Alzheimer disease (AD) is crucial for accurate interpretation of the findings.
Exposures Participants were categorized into 4 groups based on their plasma and PET biomarker results: plasma-/PET-, plasma+/PET-, plasma-/PET+, and plasma+/PET+.
Results A total of 2611 participants (mean [SD] age was 71.2 [8.7] years; 1656 female [63.4%]), of whom 124 additionally underwent tau PET, were included.
The p-tau217+/Aβ PET- group was older (mean [SD] age, 75.8 [7.2] years vs 70.0 [8.8] years; P < .001) with a higher prevalence of hypertension (56 of 152 [36.8%] vs 266 of 1073 [25.0%]), diabetes (40 of 152 [26.3%] vs 156 of 1059 [14.7%]), and chronic kidney disease (17 of 152 [11.2%] vs 21 of 1073 [2.0%]) compared with the p-tau217-/Aβ PET- group (P < .001 for all).

Why it matters

This study compared blood biomarker results with PET scans and found that p-tau217 matched amyloid and tau PET results most often, while some people had mismatched results. It is about interpreting biomarker tests, not about treating, curing, or preventing Alzheimer's disease.

New to this subject? Start with our plain-English guide: Blood tests & biomarkers →

Study details

Study designcohort study
Participants2,611
Effect size63.4%; 90.5%; 83.3%
Evidence strengthModerate

How this study scored 65/100

Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	3 / 4	2,611 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	3 / 7	Cited 24 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	8.0 citations a year over 3 year(s) since 2025
Impact for its field and year	4 / 6	Cited 15.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	2 / 4	Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Howard M Fillit: h-index 46 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multicenter collaboration	3 / 3	OpenAlex lists 41 institution(s) in 8 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39960728)
Free to read	0 / 2	Behind a paywall — scores zero
Total	65 / 100	—

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