Home › Research › Brain scans and imaging
Disproportionately Enlarged Subarachnoid-Space Hydrocephalus on MRI in Pathologically Confirmed Progressive Supranuclear Palsy
Miki Kawazoe, Shunsuke Koga, Hiroaki Sekiya, Keith A. Josephs, Neill R. Graff‐Radford, Dennis W. Dickson. Neurology Clinical Practice, 2025-02-20
Topic: Brain proteins, microglia and lab models
= 0.120). These findings suggest that DESH and high EI, often considered biomarkers for iNPH, may lack specificity and may be found in a subset of patients with PSP or LBD leading to unnecessary neurosurgery for iNPH.
Key findings
- These findings suggest that DESH and high EI, often considered biomarkers for iNPH, may lack specificity and may be found in a subset of patients with PSP or LBD leading to unnecessary neurosurgery for iNPH.
Why it matters
This study found that DESH and high Evan's index, which are often considered biomarkers for idiopathic normal pressure hydrocephalus, may also appear in some patients with progressive supranuclear palsy or Lewy body dementia. This lack of specificity could lead to unnecessary neurosurgery for idiopathic normal pressure hydrocephalus.
New to this subject? Start with our plain-English guide: Brain scans & tests →
Study details
- Participants190
- Effect size70.5%
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurology Clinical Practice) |
| Journal's citation record | 0 / 4 | Neurology Clinical Practice: journal h-index 60 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 190 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 8 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Dennis W. Dickson: h-index 218 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40007723) |
| Free to read | 2 / 2 | Free to read |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1212/cpj.0000000000200431
- PubMed: 40007723
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Kawazoe, M., Koga, S., Sekiya, H., Josephs, K. A., Graff‐Radford, N. R., & Dickson, D. W. (2025). Disproportionately Enlarged Subarachnoid-Space Hydrocephalus on MRI in Pathologically Confirmed Progressive Supranuclear Palsy. Neurology Clinical Practice. https://doi.org/10.1212/cpj.0000000000200431
Vancouver
Kawazoe M, Koga S, Sekiya H, Josephs KA, Graff‐Radford NR, Dickson DW. Disproportionately Enlarged Subarachnoid-Space Hydrocephalus on MRI in Pathologically Confirmed Progressive Supranuclear Palsy. Neurology Clinical Practice. 2025. doi:10.1212/cpj.0000000000200431. PMID: 40007723.
BibTeX
@article{kawazoe2025-40007723,
author = {Kawazoe, Miki and Koga, Shunsuke and Sekiya, Hiroaki and Josephs, Keith A. and Graff‐Radford, Neill R. and Dickson, Dennis W.},
title = {{Disproportionately Enlarged Subarachnoid-Space Hydrocephalus on MRI in Pathologically Confirmed Progressive Supranuclear Palsy}},
journal = {Neurology Clinical Practice},
year = {2025},
doi = {10.1212/cpj.0000000000200431},
pmid = {40007723},
url = {https://doi.org/10.1212/cpj.0000000000200431}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Related studies in Brain scans and imaging
Also tagged “cerebral”
900 studies in the library carry the topic tag “cerebral”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 900 tagged studies.