Home › Research › Risk factors
Associations among sleep quality, sleep duration, and Alzheimer's disease biomarkers: A systematic review and meta-analysis
Chun-Lin Chen, Miao-Yu Zhang, Zhi-Lin Wang, Jia-Hui Deng, Yan-Ping Bao, Jie Shi, Lin Lu, Le Shi. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025-03
Topic: Brain imaging, connectivity and assessment
In total, 30 studies were included comprising 14,997 subjects. Individuals with poor sleep quality exhibited greater PET Aβ burden and higher Aβ42 levels in plasma than those with good sleep quality. Shorter sleep duration was associated with higher Aβ burden on PET. However, no association between either sleep quality or sleep duration and tau levels was found. Sleep may be a modifiable marker of early AD management by modulating Aβ levels. HIGHLIGHTS: lPoor sleep quality and shorter sleep duration were significantly associated with higher amyloid beta (Aβ) burden detected by positron emission tomography (PET) in non-demented populations. Poor sleep quality was also associated with elevated Aβ42 levels in plasma. lNo significant associations were found between sleep quality or sleep duration and tau levels in plasma, cerebrospinal fluid, or PET. lInterventions targeting sleep could serve as a viable and low-cost prevention strategy for early management of Alzheimer's disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Chen, C.-L., Zhang, M.-Y., Wang, Z.-L., Deng, J.-H., Bao, Y.-P., Shi, J., et al. (2025). Associations among sleep quality, sleep duration, and Alzheimer's disease biomarkers: A systematic review and meta-analysis. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.70096
Vancouver
Chen C.-L, Zhang M.-Y, Wang Z.-L, Deng J.-H, Bao Y.-P, Shi J, et al. Associations among sleep quality, sleep duration, and Alzheimer's disease biomarkers: A systematic review and meta-analysis. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2025. doi:10.1002/alz.70096. PMID: 40145494.
BibTeX
@article{chen2025-40145494,
author = {Chen, Chun-Lin and Zhang, Miao-Yu and Wang, Zhi-Lin and Deng, Jia-Hui and Bao, Yan-Ping and Shi, Jie and Lu, Lin and Shi, Le},
title = {{Associations among sleep quality, sleep duration, and Alzheimer's disease biomarkers: A systematic review and meta-analysis}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2025},
doi = {10.1002/alz.70096},
pmid = {40145494},
url = {https://doi.org/10.1002/alz.70096}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- In total, 30 studies were included comprising 14,997 subjects.
- Individuals with poor sleep quality exhibited greater PET Aβ burden and higher Aβ42 levels in plasma than those with good sleep quality.
- Shorter sleep duration was associated with higher Aβ burden on PET.
- However, no association between either sleep quality or sleep duration and tau levels was found.
- Sleep may be a modifiable marker of early AD management by modulating Aβ levels.
New to this subject? Start with our plain-English guide: Risk factors, ranked →
Study details
- Participants14,997
- Evidence strengthLow
How this study scored 80/100
Published in a leading specialty journal, and it is a systematic review of all the studies on the question. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 45 of the 56 points we could judge it on, which is 80 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A systematic review of all the studies on the question (from PubMed type “Systematic Review”) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 4 / 4 | 14,997 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40145494) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 45 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 45 of the 56 points we could judge it on is 80 out of 100. |
| Total | 80 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Related
Studies in the library that share something with this one. The line above each title says what.
Related studies in Risk factors
Also tagged “apnea”
196 studies in the library carry the topic tag “apnea”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 196 tagged studies.