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69/100

✓ Peer-reviewed alzhub usefulness score 69 out of 100. Caregiving

Topic: Risk, prevention and care in population studies

Results This trial included 250 caregivers (mean [SD] age, 48.9 [13.8] years); most (171 [68.4%]) were female. The MBI component significantly improved multiple caregiver outcomes, with reduced depressive symptoms (β = -2.13 [95% CI, -2.85 to -1.38]; P Conclusions and relevance In this clinical trial of informal caregivers of people with dementia, synergistic interaction effects were noted for MBI, which enhanced the benefits of SC and BPM on depression.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Kwok, J. Y. Y., Cheung, D. S. K., Zarit, S., Cheung, K. S., Lau, B. H. P., Lou, V. W., et al. (2025). Multicomponent Intervention for Distressed Informal Caregivers of People With Dementia: A Randomized Clinical Trial. JAMA Network Open. https://doi.org/10.1001/jamanetworkopen.2025.0069

Vancouver

Kwok JYY, Cheung DSK, Zarit S, Cheung KS, Lau BHP, Lou VW, et al. Multicomponent Intervention for Distressed Informal Caregivers of People With Dementia: A Randomized Clinical Trial. JAMA Network Open. 2025. doi:10.1001/jamanetworkopen.2025.0069. PMID: 40094667.

BibTeX

@article{kwok2025-40094667,
  author  = {Kwok, J. Y. Y. and Cheung, D. S. K. and Zarit, S. and Cheung, K. S. and Lau, B. H. P. and Lou, V. W. and Cheng, S. T. and Gallagher-Thompson, D. and Qian, M. and Chou, K. L.},
  title   = {{Multicomponent Intervention for Distressed Informal Caregivers of People With Dementia: A Randomized Clinical Trial}},
  journal = {JAMA Network Open},
  year    = {2025},
  doi     = {10.1001/jamanetworkopen.2025.0069},
  pmid    = {40094667},
  url     = {https://doi.org/10.1001/jamanetworkopen.2025.0069}
}

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Key findings

Results This trial included 250 caregivers (mean [SD] age, 48.9 [13.8] years); most (171 [68.4%]) were female.
The MBI component significantly improved multiple caregiver outcomes, with reduced depressive symptoms (β = -2.13 [95% CI, -2.85 to -1.38]; P < .001) and increased mindfulness (β = 4.23 [95% CI, 2.27-6.36]; P < .001), perceived social support (β = 4.76 [95% CI, 1.28-8.15]; P = .007), and active dementia care management (β = 3.70 [95% CI, 1.80-5.66]; P < .001) at 12 months.

Why it matters

In this trial of 250 caregivers, the multicomponent intervention reduced depressive symptoms and improved multiple caregiver outcomes. The findings suggest that combining intervention components may help ease depression in people caring for someone with dementia.

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Study details

Study designRCT
Participants250
Effect sizeMindfulness component: PHQ-9 depressive symptoms β = -2.13 (95% CI -2.85 to -1.38) at 12 months
Evidence strengthModerate

Limitations

Single city (Hong Kong) with Chinese caregivers; factorial design means each component's estimate pools across many combinations; self-reported outcomes.

How this study scored 69/100

Published in a leading specialty journal, and it is a randomised controlled trial. We have no data on free to read, so that was left out: it earned 68 of the 98 points we could judge it on, which is 69 out of 100.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA Network Open)
Journal's citation record	2 / 4	JAMA Network Open: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	11 / 12	A randomised controlled trial
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	250 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	1 / 2	Randomised (as stated in the record)
Times cited	2 / 7	Cited 14 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	4.7 citations a year over 3 year(s) since 2025
Impact for its field and year	4 / 6	Cited 8.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Kee‐Lee Chou: h-index 53 (OpenAlex, whole career)
Institution's track record	3 / 3	Harvard University: institution h-index 3,235 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 13 institution(s) in 4 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40094667)
Free to read	— / 2	Access not recorded — left out of this score
Points	68 / 98	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 68 of the 98 points we could judge it on is 69 out of 100.
Total	69 / 100	—

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Read the original

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