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60/100

✓ Peer-reviewed alzhub usefulness score 60 out of 100. Vascular contributions

Topic: Amyloid, tau and blood-test diagnosis

Plain-language summary

Among 4712 participants (59% female; mean age, 74 years), 193 ischemic strokes and 769 dementia cases were ascertained over a median follow-up of 8.3 years. Of LA myopathy markers, only LA reservoir strain and NT-proBNP significantly improved C statistic when added to the CHA 2 DS 2 -VASc model (base C statistic, 0.677) for the prediction of the composite outcome. Adding the LA reservoir yielded the highest increase in C statistic (0.010 [95% CI, 0.003–0.017]), and the model including the LA reservoir showed the lowest Akaike information criterion. In multivariable regression models, LA volume index, NT-proBNP, and LA strain parameters were significantly associated with the composite outcome. Of various LA myopathy markers, LA reservoir yields the greatest improvement in the prediction of ischemic stroke and dementia, supporting its use to identify people at high risk of cerebrovascular events and dementia.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Masini, G., Wang, W., Ji, Y., Eaton, A. A., Inciardi, R. M., Soliman, E. Z., et al. (2025). Markers of Left Atrial Myopathy: Prognostic Usefulness for Ischemic Stroke and Dementia in People in Sinus Rhythm. Stroke. https://doi.org/10.1161/strokeaha.124.047747

Vancouver

Masini G, Wang W, Ji Y, Eaton AA, Inciardi RM, Soliman EZ, et al. Markers of Left Atrial Myopathy: Prognostic Usefulness for Ischemic Stroke and Dementia in People in Sinus Rhythm. Stroke. 2025. doi:10.1161/strokeaha.124.047747. PMID: 40052267.

BibTeX

@article{masini2025-40052267,
  author  = {Masini, Gabriele and Wang, Wendy and Ji, Yuekai and Eaton, Anne A. and Inciardi, Riccardo Maria and Soliman, Elsayed Z. and PASSMAN, ROD S. and Solomon, Scott David and others},
  title   = {{Markers of Left Atrial Myopathy: Prognostic Usefulness for Ischemic Stroke and Dementia in People in Sinus Rhythm}},
  journal = {Stroke},
  year    = {2025},
  doi     = {10.1161/strokeaha.124.047747},
  pmid    = {40052267},
  url     = {https://doi.org/10.1161/strokeaha.124.047747}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

How to read this study

Design: this is a follow-up (cohort) study. People are observed over time and not assigned to anything, so an association can reflect other differences between groups. Look at how long follow-up lasted, how many dropped out, and whether the authors adjusted for age, education and other health conditions.
Size: the record lists 4,712 participants. Ask whether that is enough for the question, and who they were.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded moderate. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Moderate means the abstract mentions a cohort, case-control or longitudinal design. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Among 4712 participants (59% female; mean age, 74 years), 193 ischemic strokes and 769 dementia cases were ascertained over a median follow-up of 8.3 years.
Of LA myopathy markers, only LA reservoir strain and NT-proBNP significantly improved C statistic when added to the CHA 2 DS 2 -VASc model (base C statistic, 0.677) for the prediction of the composite outcome.
Adding the LA reservoir yielded the highest increase in C statistic (0.010 [95% CI, 0.003–0.017]), and the model including the LA reservoir showed the lowest Akaike information criterion.
In multivariable regression models, LA volume index, NT-proBNP, and LA strain parameters were significantly associated with the composite outcome.
Of various LA myopathy markers, LA reservoir yields the greatest improvement in the prediction of ischemic stroke and dementia, supporting its use to identify people at high risk of cerebrovascular events and dementia.

Why it matters

In this cohort study, left atrial reservoir strain and NT-proBNP improved prediction of a combined outcome of ischemic stroke and dementia when added to a standard risk model. The authors support using left atrial reservoir strain to identify people at high risk of cerebrovascular events and dementia, but the study does not test any treatment, cure, or prevention.

Study details

Study designcohort study
Participants4,712
Evidence strengthModerate

How this study scored 60/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Stroke)
Journal's citation record	3 / 4	Stroke: journal h-index 455 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	3 / 4	4,712 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 7 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	2.3 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 4.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Lin Y. Chen: h-index 65 (OpenAlex, whole career)
Institution's track record	3 / 3	Harvard University: institution h-index 3,235 (OpenAlex)
Multicenter collaboration	3 / 3	OpenAlex lists 10 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40052267)
Free to read	2 / 2	Free to read
Total	60 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

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