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Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia
Xulin Liu, Sterre C.M. de Boer, Kasey Cortez, Jackie M. Poos, Ignacio Illán‐Gala, Hilary W. Heuer, Leah K. Forsberg, Kaitlin Blackstone Casaletto et al.. Alzheimer s & Dementia, 2025-04-01
Topic: Risk, prevention and care in population studies
Females with sporadic bvFTD showed worse compulsive behavior (p = 0.026) and language impairments (p = 0.024) compared to females with genetic bvFTD (n = 152). Genetic bvFTD females had smaller gray matter volumes than sporadic bvFTD females, particularly in the parietal lobe. Females with sporadic bvFTD exhibit a distinct clinical phenotype compared to females with genetic bvFTD. This difference may explain the discrepancy in prevalence between genetic and sporadic cases, as some females without genetic mutations may be misdiagnosed due to atypical bvFTD symptom presentation. HIGHLIGHTS: Sex ratio is equal in genetic behavioral variant of frontotemporal dementia (bvFTD), whereas more males are present in sporadic bvFTD. Distinct neuropsychiatric phenotypes exist between sporadic and genetic bvFTD in females. Phenotype might explain the sex ratio difference between sporadic and genetic cases.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Liu, X., de Boer, S. C., Cortez, K., Poos, J. M., Illán‐Gala, I., Heuer, H. W., et al. (2025). Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia. Alzheimer s & Dementia. https://doi.org/10.1002/alz.14608
Vancouver
Liu X, de Boer SC, Cortez K, Poos JM, Illán‐Gala I, Heuer HW, et al. Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia. Alzheimer s & Dementia. 2025. doi:10.1002/alz.14608. PMID: 40277074.
BibTeX
@article{liu2025-40277074,
author = {Liu, Xulin and de Boer, Sterre C.M. and Cortez, Kasey and Poos, Jackie M. and Illán‐Gala, Ignacio and Heuer, Hilary W. and Forsberg, Leah K. and Casaletto, Kaitlin Blackstone and others},
title = {{Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.14608},
pmid = {40277074},
url = {https://doi.org/10.1002/alz.14608}
}
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Key findings
- Females with sporadic bvFTD showed worse compulsive behavior (p = 0.026) and language impairments (p = 0.024) compared to females with genetic bvFTD (n = 152).
- Genetic bvFTD females had smaller gray matter volumes than sporadic bvFTD females, particularly in the parietal lobe.
- Females with sporadic bvFTD exhibit a distinct clinical phenotype compared to females with genetic bvFTD.
- This difference may explain the discrepancy in prevalence between genetic and sporadic cases, as some females without genetic mutations may be misdiagnosed due to atypical bvFTD symptom presentation.
- HIGHLIGHTS: Sex ratio is equal in genetic behavioral variant of frontotemporal dementia (bvFTD), whereas more males are present in sporadic bvFTD.
Why it matters
Females with sporadic behavioral-variant frontotemporal dementia showed worse compulsive behavior and language impairments compared to females with genetic bvFTD, and genetic bvFTD females had smaller gray matter volumes particularly in the parietal lobe. This difference may explain the discrepancy in prevalence between genetic and sporadic cases, as some females without genetic mutations may be misdiagnosed due to atypical symptom presentation.
Study details
- Participants152
- Evidence strengthLow
How this study scored 52/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 152 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 9 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 1 / 4 | Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Maria Carmela Tartaglia: h-index 64 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | University of Washington: institution h-index 3,540 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 85 institution(s) in 12 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40277074) |
| Free to read | 2 / 2 | Free to read |
| Total | 52 / 100 | — |
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