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Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community
Takahiro Morito, Meng Qi, Naoko Kamano, Hiroki Sasaguri, Sumi Bez, Martha S. Foiani, Karen Duff, Seico Benner et al.. Cell Reports Methods, 2025-04-01
Topic: Brain proteins, microglia and lab models
Existing models of frontotemporal dementia (FTD) may not fully recapitulate the pathophysiology of the disease. To generate more pathophysiologically relevant FTD models, we engineered MAPT knockin mouse lines carrying triple mutations, among which the MAPT P301S;Int10+3;S320F line exhibited robust tau pathology starting before 6 months of age. Severe tau accumulation was predominantly observed in the thalamus, hypothalamus, and amygdala with milder involvement of the cortex and hippocampus, leading to synaptic loss, brain atrophy, and FTD-like behavioral abnormalities. Crossbreeding MAPT P301S;Int10+3;S320F mice with App knockin, App NL-G-F , mice markedly enhanced tau pathology in the cortex and hippocampus, highlighting the interplay between β-amyloid and tau. These findings establish the mutant mice as valuable models for investigating the mechanisms underlying FTD and other tauopathies, providing a relevant platform for in vivo drug screening.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Morito, T., Qi, M., Kamano, N., Sasaguri, H., Bez, S., Foiani, M. S., et al. (2025). Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community. Cell Reports Methods. https://doi.org/10.1016/j.crmeth.2025.101024
Vancouver
Morito T, Qi M, Kamano N, Sasaguri H, Bez S, Foiani MS, et al. Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community. Cell Reports Methods. 2025. doi:10.1016/j.crmeth.2025.101024. PMID: 40220760.
BibTeX
@article{morito2025-40220760,
author = {Morito, Takahiro and Qi, Meng and Kamano, Naoko and Sasaguri, Hiroki and Bez, Sumi and Foiani, Martha S. and Duff, Karen and Benner, Seico and others},
title = {{Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community}},
journal = {Cell Reports Methods},
year = {2025},
doi = {10.1016/j.crmeth.2025.101024},
pmid = {40220760},
url = {https://doi.org/10.1016/j.crmeth.2025.101024}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- These findings establish the mutant mice as valuable models for investigating the mechanisms underlying FTD and other tauopathies, providing a relevant platform for in vivo drug screening.
Why it matters
Engineered MAPT knockin mouse lines exhibited robust tau pathology, synaptic loss, brain atrophy, and FTD-like behavioral abnormalities, establishing them as valuable models for investigating mechanisms underlying FTD and other tauopathies. These mice provide a relevant platform for in vivo drug screening, based on animal models.
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cell Reports Methods) |
| Journal's citation record | 0 / 4 | Cell Reports Methods: journal h-index 45 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mouse”) — scores zero |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 11 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 6.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Naoto Watamura: h-index 15 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40220760) |
| Free to read | 2 / 2 | Free to read |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.crmeth.2025.101024
- PubMed: 40220760
- Original source →
- Free full text: Cell Reports Methods →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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